EPR on medically relevant NO adsorbed to Zn-LTA

C. Pal; P. S. Wheatley; H. El Mkami; D. J. Keeble; R. E. Morris; Olav Schiemann

doi:10.1007/s00723-009-0071-x

EPR on medically relevant NO adsorbed to Zn-LTA

C. Pal, P. S. Wheatley, H. El Mkami, D. J. Keeble, R. E. Morris, Olav Schiemann

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

For medical purposes, materials are required that store and target specifically deliver exogenous nitric oxide (NO). Partially zinc-exchanged Na-LTA (Linde type A) zeolite (Zn-LTA) has high potential in this respect due to its non-toxicity and adsorption capacity for NO. In contrast to NO adsorbed to LTA zeolites prepared for catalytic purposes, lower dehydration temperature prior to NO adsorption is used to achieve a balance between production cost and high activity. In order to study the interaction of NO with the metal sites in the samples prepared under these medical conditions, continuous-wave X-band electron paramagnetic resonance has been applied. In contrast to Na-LTA with only one weakly interacting NO monomer, three different monomers, having stronger interaction to the metal sites than in Na-LTA, were observed in Zn-LTA. To improve the storage capacity of Zn-LTA, higher dehydration temperatures would be necessary.

Original language	English
Pages (from-to)	619-627
Number of pages	9
Journal	Applied Magnetic Resonance
Volume	37
Issue number	1
DOIs	https://doi.org/10.1007/s00723-009-0071-x
State	Published - 2010
Externally published	Yes

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title = "EPR on medically relevant NO adsorbed to Zn-LTA",

abstract = "For medical purposes, materials are required that store and target specifically deliver exogenous nitric oxide (NO). Partially zinc-exchanged Na-LTA (Linde type A) zeolite (Zn-LTA) has high potential in this respect due to its non-toxicity and adsorption capacity for NO. In contrast to NO adsorbed to LTA zeolites prepared for catalytic purposes, lower dehydration temperature prior to NO adsorption is used to achieve a balance between production cost and high activity. In order to study the interaction of NO with the metal sites in the samples prepared under these medical conditions, continuous-wave X-band electron paramagnetic resonance has been applied. In contrast to Na-LTA with only one weakly interacting NO monomer, three different monomers, having stronger interaction to the metal sites than in Na-LTA, were observed in Zn-LTA. To improve the storage capacity of Zn-LTA, higher dehydration temperatures would be necessary.",

author = "C. Pal and Wheatley, {P. S.} and Mkami, {H. El} and Keeble, {D. J.} and Morris, {R. E.} and Olav Schiemann",

note = "Funding Information: Acknowledgments The financial support of the German Research Foundation (DFG, SCHI 531/5-2) and of the Engineering and Physical Sciences Research Council is gratefully acknowledged.",

year = "2010",

doi = "10.1007/s00723-009-0071-x",

language = "English",

volume = "37",

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journal = "Applied Magnetic Resonance",

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T1 - EPR on medically relevant NO adsorbed to Zn-LTA

AU - Pal, C.

AU - Wheatley, P. S.

AU - Mkami, H. El

AU - Keeble, D. J.

AU - Morris, R. E.

AU - Schiemann, Olav

N1 - Funding Information: Acknowledgments The financial support of the German Research Foundation (DFG, SCHI 531/5-2) and of the Engineering and Physical Sciences Research Council is gratefully acknowledged.

PY - 2010

Y1 - 2010

N2 - For medical purposes, materials are required that store and target specifically deliver exogenous nitric oxide (NO). Partially zinc-exchanged Na-LTA (Linde type A) zeolite (Zn-LTA) has high potential in this respect due to its non-toxicity and adsorption capacity for NO. In contrast to NO adsorbed to LTA zeolites prepared for catalytic purposes, lower dehydration temperature prior to NO adsorption is used to achieve a balance between production cost and high activity. In order to study the interaction of NO with the metal sites in the samples prepared under these medical conditions, continuous-wave X-band electron paramagnetic resonance has been applied. In contrast to Na-LTA with only one weakly interacting NO monomer, three different monomers, having stronger interaction to the metal sites than in Na-LTA, were observed in Zn-LTA. To improve the storage capacity of Zn-LTA, higher dehydration temperatures would be necessary.

AB - For medical purposes, materials are required that store and target specifically deliver exogenous nitric oxide (NO). Partially zinc-exchanged Na-LTA (Linde type A) zeolite (Zn-LTA) has high potential in this respect due to its non-toxicity and adsorption capacity for NO. In contrast to NO adsorbed to LTA zeolites prepared for catalytic purposes, lower dehydration temperature prior to NO adsorption is used to achieve a balance between production cost and high activity. In order to study the interaction of NO with the metal sites in the samples prepared under these medical conditions, continuous-wave X-band electron paramagnetic resonance has been applied. In contrast to Na-LTA with only one weakly interacting NO monomer, three different monomers, having stronger interaction to the metal sites than in Na-LTA, were observed in Zn-LTA. To improve the storage capacity of Zn-LTA, higher dehydration temperatures would be necessary.

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DO - 10.1007/s00723-009-0071-x

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VL - 37

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JO - Applied Magnetic Resonance

JF - Applied Magnetic Resonance

IS - 1

ER -

EPR on medically relevant NO adsorbed to Zn-LTA

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