Epigenomic differences between osteoarthritis grades in primary cartilage

Peter Kreitmaier, Diane Swift, J. Mark Wilkinson, Eleftheria Zeggini

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: Osteoarthritis is a common and complex joint disorder that shows higher prevalence and greater disease severity in women. Here, we investigate genome-wide methylation profiles of primary chondrocytes from osteoarthritis patients. Design: We compare genome-wide methylation profiles of macroscopically intact (low-grade) and degraded (high-grade) osteoarthritis cartilage samples matched from osteoarthritis patients undergoing knee replacement surgery. We perform an epigenome-wide association study for cartilage degeneration across 170 patients and separately in 96 women and 74 men. Results: We reveal widespread epigenetic differences with enrichments of nervous system and apoptosis-related processes. We further identify substantial similarities between sexes, but also sex-specific markers and pathways. Conclusions: Together, we provide the largest genome-wide methylation profiles of primary cartilage to date with enhanced and sex-specific insights into epigenetic processes underlying osteoarthritis progression.

Original languageEnglish
Pages (from-to)1126-1133
Number of pages8
JournalOsteoarthritis and Cartilage
Volume32
Issue number9
DOIs
StatePublished - Sep 2024

Keywords

  • Cartilage
  • Chondrocytes
  • DNA methylation
  • EWAS
  • Osteoarthritis
  • Sex specificity

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