Epigenome dynamics: A quantitative genetics perspective

Frank Johannes, Vincent Colot, Ritsert C. Jansen

Research output: Contribution to journalReview articlepeer-review

175 Scopus citations


Classically, quantitative geneticists have envisioned DNA sequence variants as the only source of heritable phenotypes. This view should be revised in light of accumulating evidence for widespread epigenetic variation in natural and experimental populations. Here we argue that it is timely to consider novel experimental strategies and analysis models to capture the potentially dynamic interplay between chromatin and DNA sequence factors in complex traits.

Original languageEnglish
Pages (from-to)883-890
Number of pages8
JournalNature Reviews Genetics
Issue number11
StatePublished - Nov 2008
Externally publishedYes


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