Epigenetic Priming in Cancer Initiation

Carolina Vicente-Dueñas; Julia Hauer; César Cobaleda; Arndt Borkhardt; Isidro Sánchez-García

doi:10.1016/j.trecan.2018.04.007

Epigenetic Priming in Cancer Initiation

Carolina Vicente-Dueñas
, Julia Hauer
, César Cobaleda
, Arndt Borkhardt
, Isidro Sánchez-García

Institute of Biomedical Research of Salamanca (IBSAL)
Heinrich-Heine-University
CBMSO (CSIC-UAM)
Universidad de Salamanca

Research output: Contribution to journal › Review article › peer-review

89 Scopus citations

Abstract

Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of oncogenes to cancer development is mediated mainly through epigenetic priming of cancer-initiating cells, suggesting that genetic lesions that initiate the cancer process might be dispensable for the posterior tumor progression and maintenance. Epigenetic priming may remain latent until it is later triggered by endogenous or environmental stimuli. This Opinion article addresses the impact of epigenetic priming in cancer development and in the design of new therapeutic approaches.

Original language	English
Pages (from-to)	408-417
Number of pages	10
Journal	Trends in Cancer
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/j.trecan.2018.04.007
State	Published - Jun 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
cancer stem cell
cancer therapy
oncogenes
reprogramming
stem cells

Access to Document

10.1016/j.trecan.2018.04.007

Cite this

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title = "Epigenetic Priming in Cancer Initiation",

abstract = "Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of oncogenes to cancer development is mediated mainly through epigenetic priming of cancer-initiating cells, suggesting that genetic lesions that initiate the cancer process might be dispensable for the posterior tumor progression and maintenance. Epigenetic priming may remain latent until it is later triggered by endogenous or environmental stimuli. This Opinion article addresses the impact of epigenetic priming in cancer development and in the design of new therapeutic approaches.",

keywords = "cancer, cancer stem cell, cancer therapy, oncogenes, reprogramming, stem cells",

author = "Carolina Vicente-Due{\~n}as and Julia Hauer and C{\'e}sar Cobaleda and Arndt Borkhardt and Isidro S{\'a}nchez-Garc{\'i}a",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = jun,

doi = "10.1016/j.trecan.2018.04.007",

language = "English",

volume = "4",

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journal = "Trends in Cancer",

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TY - JOUR

T1 - Epigenetic Priming in Cancer Initiation

AU - Vicente-Dueñas, Carolina

AU - Hauer, Julia

AU - Cobaleda, César

AU - Borkhardt, Arndt

AU - Sánchez-García, Isidro

PY - 2018/6

Y1 - 2018/6

N2 - Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of oncogenes to cancer development is mediated mainly through epigenetic priming of cancer-initiating cells, suggesting that genetic lesions that initiate the cancer process might be dispensable for the posterior tumor progression and maintenance. Epigenetic priming may remain latent until it is later triggered by endogenous or environmental stimuli. This Opinion article addresses the impact of epigenetic priming in cancer development and in the design of new therapeutic approaches.

AB - Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of oncogenes to cancer development is mediated mainly through epigenetic priming of cancer-initiating cells, suggesting that genetic lesions that initiate the cancer process might be dispensable for the posterior tumor progression and maintenance. Epigenetic priming may remain latent until it is later triggered by endogenous or environmental stimuli. This Opinion article addresses the impact of epigenetic priming in cancer development and in the design of new therapeutic approaches.

KW - cancer

KW - cancer stem cell

KW - cancer therapy

KW - oncogenes

KW - reprogramming

KW - stem cells

UR - https://www.scopus.com/pages/publications/85047201684

U2 - 10.1016/j.trecan.2018.04.007

DO - 10.1016/j.trecan.2018.04.007

M3 - Review article

C2 - 29860985

AN - SCOPUS:85047201684

SN - 2405-8033

VL - 4

SP - 408

EP - 417

JO - Trends in Cancer

JF - Trends in Cancer

IS - 6

ER -

Epigenetic Priming in Cancer Initiation

Abstract

UN SDGs

Keywords

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