Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Daniel Garbe; Stephan A. Sieber; Nina G. Bandur; Ulrich Koert; Mohamed A. Marahiel

doi:10.1002/cbic.200400042

Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Daniel Garbe, Stephan A. Sieber, Nina G. Bandur, Ulrich Koert, Mohamed A. Marahiel

Philipps-Universität Marburg

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.

Original language	English
Pages (from-to)	1000-1003
Number of pages	4
Journal	ChemBioChem
Volume	5
Issue number	7
DOIs	https://doi.org/10.1002/cbic.200400042
State	Published - 5 Jul 2004
Externally published	Yes

Keywords

Alkene dipeptide isostere
Antibiotics
Peptide cyclases
Peptidomimetics
Postsynthetic modification

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10.1002/cbic.200400042

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title = "Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres",

abstract = "A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.",

keywords = "Alkene dipeptide isostere, Antibiotics, Peptide cyclases, Peptidomimetics, Postsynthetic modification",

author = "Daniel Garbe and Sieber, \{Stephan A.\} and Bandur, \{Nina G.\} and Ulrich Koert and Marahiel, \{Mohamed A.\}",

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AU - Garbe, Daniel

AU - Sieber, Stephan A.

AU - Bandur, Nina G.

AU - Koert, Ulrich

AU - Marahiel, Mohamed A.

PY - 2004/7/5

Y1 - 2004/7/5

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AB - A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.

KW - Alkene dipeptide isostere

KW - Antibiotics

KW - Peptide cyclases

KW - Peptidomimetics

KW - Postsynthetic modification

UR - https://www.scopus.com/pages/publications/4544240965

U2 - 10.1002/cbic.200400042

DO - 10.1002/cbic.200400042

M3 - Article

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SN - 1439-4227

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JO - ChemBioChem

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Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Abstract

Keywords

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