Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Daniel Garbe, Stephan A. Sieber, Nina G. Bandur, Ulrich Koert, Mohamed A. Marahiel

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.

Original languageEnglish
Pages (from-to)1000-1003
Number of pages4
JournalChemBioChem
Volume5
Issue number7
DOIs
StatePublished - 5 Jul 2004
Externally publishedYes

Keywords

  • Alkene dipeptide isostere
  • Antibiotics
  • Peptide cyclases
  • Peptidomimetics
  • Postsynthetic modification

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