Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Daniel Garbe; Stephan A. Sieber; Nina G. Bandur; Ulrich Koert; Mohamed A. Marahiel

doi:10.1002/cbic.200400042

Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Daniel Garbe, Stephan A. Sieber, Nina G. Bandur, Ulrich Koert, Mohamed A. Marahiel

Philipps-Universität Marburg

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.

Original language	English
Pages (from-to)	1000-1003
Number of pages	4
Journal	ChemBioChem
Volume	5
Issue number	7
DOIs	https://doi.org/10.1002/cbic.200400042
State	Published - 5 Jul 2004
Externally published	Yes

Keywords

Alkene dipeptide isostere
Antibiotics
Peptide cyclases
Peptidomimetics
Postsynthetic modification

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10.1002/cbic.200400042

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abstract = "A key to the development of new antibiotics with increased efficiency can be found in (E)-alkene dipeptide isosteres. Here we report on the incorporation of such a dipeptide isostere into a linear peptide precursor by chemical synthesis in combination with enzymatic cyclisation.",

keywords = "Alkene dipeptide isostere, Antibiotics, Peptide cyclases, Peptidomimetics, Postsynthetic modification",

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AU - Koert, Ulrich

AU - Marahiel, Mohamed A.

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KW - Antibiotics

KW - Peptide cyclases

KW - Peptidomimetics

KW - Postsynthetic modification

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Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres

Abstract

Keywords

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