Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

Inge Sillaber; Gerhard Rammes; Stephan Zimmermann; Beatrice Mahal; Walter Zieglgänsberger; Wolfgang Wurst; Florian Holsboer; Rainer Spanagel

doi:10.1126/science.1069836

Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

Inge Sillaber, Gerhard Rammes, Stephan Zimmermann, Beatrice Mahal, Walter Zieglgänsberger, Wolfgang Wurst, Florian Holsboer, Rainer Spanagel

Max Planck Institute of Psychiatry

Research output: Contribution to journal › Article › peer-review

206 Scopus citations

Abstract

There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-D-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism.

Original language	English
Pages (from-to)	931-933
Number of pages	3
Journal	Science
Volume	296
Issue number	5569
DOIs	https://doi.org/10.1126/science.1069836
State	Published - 3 May 2002
Externally published	Yes

Access to Document

10.1126/science.1069836

Cite this

@article{a1174c00dca144028ba30a2a29ada175,

title = "Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors",

abstract = "There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-D-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism.",

author = "Inge Sillaber and Gerhard Rammes and Stephan Zimmermann and Beatrice Mahal and Walter Zieglg{\"a}nsberger and Wolfgang Wurst and Florian Holsboer and Rainer Spanagel",

year = "2002",

month = may,

day = "3",

doi = "10.1126/science.1069836",

language = "English",

volume = "296",

pages = "931--933",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5569",

}

TY - JOUR

T1 - Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

AU - Sillaber, Inge

AU - Rammes, Gerhard

AU - Zimmermann, Stephan

AU - Mahal, Beatrice

AU - Zieglgänsberger, Walter

AU - Wurst, Wolfgang

AU - Holsboer, Florian

AU - Spanagel, Rainer

PY - 2002/5/3

Y1 - 2002/5/3

N2 - There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-D-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism.

AB - There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-D-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism.

UR - http://www.scopus.com/inward/record.url?scp=0037012953&partnerID=8YFLogxK

U2 - 10.1126/science.1069836

DO - 10.1126/science.1069836

M3 - Article

C2 - 11988580

AN - SCOPUS:0037012953

SN - 0036-8075

VL - 296

SP - 931

EP - 933

JO - Science

JF - Science

IS - 5569

ER -

Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

Abstract

Access to Document

Other files and links

Fingerprint

Cite this