Energetic depression caused by mitochondrial dysfunction

Frank Norbert Gellerich, Sonata Trumbeckaite, Ying Chen, Marcus Deschauer, Tobias Müller, Stephan Zierz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Mitochondria not only provide most of the ATP needed for cell work and numerous specific anabolic and catabolic functions, they also contribute to Ca++ signalling and play a key role in the pathway to cell death. Impairment of mitochondrial functions caused by mutations of the mt-genome or by acute processes, is responsible for numerous diseases. Decreased concentrations of adenine nucleotides, leaky outer and inner mitochondrial membranes, and decreased activities of respiratory chain enzymes contribute to depression of cellular energy metabolism, one of the most important consequences of mitochondrial impairment as characterized by decreased cytosolic phosphorylation potentials.

Original languageEnglish
Pages (from-to)395-397
Number of pages3
JournalEuropean Cytokine Network
Volume13
Issue number4
StatePublished - Oct 2002
Externally publishedYes

Keywords

  • Inner membrane
  • Mitochondria
  • Mitochondrial disease
  • Outer membrane
  • Phosphorylation potential
  • Sepsis

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