Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias

Thomas Kohl; Ulrich Gembruch; Barbara Filsinger; Rudolf Hering; Jörgen Bruhn; Kristina Tchatcheva; Sebastian Aryee; Axel Franz; Axel Heep; Andreas Müller; Peter Bartmann; Steffan Loff; Stuart Hosie; Wolfgang Neff; Thomas Schaible

doi:10.1159/000091363

Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias

Thomas Kohl, Ulrich Gembruch, Barbara Filsinger, Rudolf Hering, Jörgen Bruhn, Kristina Tchatcheva, Sebastian Aryee, Axel Franz, Axel Heep, Andreas Müller, Peter Bartmann, Steffan Loff, Stuart Hosie, Wolfgang Neff, Thomas Schaible

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Objective: In order to assess the effect of deliberately delayed percutaneous fetoscopic tracheal occlusion on survival of fetuses with life-threatening congenital diaphragmatic hernia. Methods: Eight fetuses with life-threatening congenital diaphragmatic hernia underwent fetoscopic tracheal balloon occlusion between 29 + 0 and 32 + 4 weeks of gestation. Delayed occlusion was chosen in order to minimize potentially negative pulmonary effects from premature delivery as a result of fetal surgery. In addition, we wanted to become able to provide all available postnatal intensive care treatment means in these patients. Results: Six of the 8 fetuses survived to discharge from hospital. Conclusion: Delayed fetoscopic tracheal balloon occlusion may be rewarded with lung growth sufficient to allow survival of fetuses with life-threatening congenital diaphragmatic hernia.

Original language	English
Pages (from-to)	314-318
Number of pages	5
Journal	Fetal Diagnosis and Therapy
Volume	21
Issue number	3
DOIs	https://doi.org/10.1159/000091363
State	Published - Apr 2006
Externally published	Yes

Keywords

Congenital diaphragmatic hernia
Endoscopy
FETENDO
Fetal surgery
Fetoscopic tracheal occlusion
Fetoscopy
Lung disease
Pulmonary hypoplasia
Tracheal balloon occlusion

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10.1159/000091363

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Kohl, T., Gembruch, U., Filsinger, B., Hering, R., Bruhn, J., Tchatcheva, K., Aryee, S., Franz, A., Heep, A., Müller, A., Bartmann, P., Loff, S., Hosie, S., Neff, W., & Schaible, T. (2006). Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias. Fetal Diagnosis and Therapy, 21(3), 314-318. https://doi.org/10.1159/000091363

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title = "Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias",

abstract = "Objective: In order to assess the effect of deliberately delayed percutaneous fetoscopic tracheal occlusion on survival of fetuses with life-threatening congenital diaphragmatic hernia. Methods: Eight fetuses with life-threatening congenital diaphragmatic hernia underwent fetoscopic tracheal balloon occlusion between 29 + 0 and 32 + 4 weeks of gestation. Delayed occlusion was chosen in order to minimize potentially negative pulmonary effects from premature delivery as a result of fetal surgery. In addition, we wanted to become able to provide all available postnatal intensive care treatment means in these patients. Results: Six of the 8 fetuses survived to discharge from hospital. Conclusion: Delayed fetoscopic tracheal balloon occlusion may be rewarded with lung growth sufficient to allow survival of fetuses with life-threatening congenital diaphragmatic hernia.",

keywords = "Congenital diaphragmatic hernia, Endoscopy, FETENDO, Fetal surgery, Fetoscopic tracheal occlusion, Fetoscopy, Lung disease, Pulmonary hypoplasia, Tracheal balloon occlusion",

author = "Thomas Kohl and Ulrich Gembruch and Barbara Filsinger and Rudolf Hering and J{\"o}rgen Bruhn and Kristina Tchatcheva and Sebastian Aryee and Axel Franz and Axel Heep and Andreas M{\"u}ller and Peter Bartmann and Steffan Loff and Stuart Hosie and Wolfgang Neff and Thomas Schaible",

year = "2006",

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doi = "10.1159/000091363",

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Kohl, T, Gembruch, U, Filsinger, B, Hering, R, Bruhn, J, Tchatcheva, K, Aryee, S, Franz, A, Heep, A, Müller, A, Bartmann, P, Loff, S, Hosie, S, Neff, W & Schaible, T 2006, 'Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias', Fetal Diagnosis and Therapy, vol. 21, no. 3, pp. 314-318. https://doi.org/10.1159/000091363

Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias. / Kohl, Thomas; Gembruch, Ulrich; Filsinger, Barbara et al.
In: Fetal Diagnosis and Therapy, Vol. 21, No. 3, 04.2006, p. 314-318.

Research output: Contribution to journal › Article › peer-review

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AU - Kohl, Thomas

AU - Gembruch, Ulrich

AU - Filsinger, Barbara

AU - Hering, Rudolf

AU - Bruhn, Jörgen

AU - Tchatcheva, Kristina

AU - Aryee, Sebastian

AU - Franz, Axel

AU - Heep, Axel

AU - Müller, Andreas

AU - Bartmann, Peter

AU - Loff, Steffan

AU - Hosie, Stuart

AU - Neff, Wolfgang

AU - Schaible, Thomas

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AB - Objective: In order to assess the effect of deliberately delayed percutaneous fetoscopic tracheal occlusion on survival of fetuses with life-threatening congenital diaphragmatic hernia. Methods: Eight fetuses with life-threatening congenital diaphragmatic hernia underwent fetoscopic tracheal balloon occlusion between 29 + 0 and 32 + 4 weeks of gestation. Delayed occlusion was chosen in order to minimize potentially negative pulmonary effects from premature delivery as a result of fetal surgery. In addition, we wanted to become able to provide all available postnatal intensive care treatment means in these patients. Results: Six of the 8 fetuses survived to discharge from hospital. Conclusion: Delayed fetoscopic tracheal balloon occlusion may be rewarded with lung growth sufficient to allow survival of fetuses with life-threatening congenital diaphragmatic hernia.

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Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias

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Keywords

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