Enantioselective synthesis of amines: General, efficient iron-catalyzed asymmetric transfer hydrogenation of imines

Shaolin Zhou, Steffen Fleischer, Kathrin Junge, Shoubhik Das, Daniele Addis, Matthias Beller

Research output: Contribution to journalArticlepeer-review

177 Scopus citations

Abstract

In the iron age: A readily accessible, active iron catalyst serves in the straightforward, catalytic transfer hydrogenation of imines (see scheme). A series of imines are converted into chiral amines in high yields and very good enantioselectivities. This method should find broad application in the search for bioactive chiral amines.

Original languageEnglish
Pages (from-to)8121-8125
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume49
Issue number44
DOIs
StatePublished - 25 Oct 2010
Externally publishedYes

Keywords

  • Asymmetric catalysis
  • Enantioselectivity
  • Imines
  • Iron catalysis
  • Transfer hydrogenation

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