Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas

Heqing Shen; H. E. Virtanen; Katharina M. Main; M. Kaleva; A. M. Andersson; Niels E. Skakkebæk; Jorma Toppari; Karl Werner Schramm

doi:10.1016/j.chemosphere.2005.04.100

Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas

Heqing Shen
, H. E. Virtanen
, Katharina M. Main
, M. Kaleva
, A. M. Andersson
, Niels E. Skakkebæk
, Jorma Toppari
, Karl Werner Schramm

Helmholtz Zentrum München German Research Center for Environmental Health
University of Turku and Turku University Hospital
Rigshospitalet

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The enantiomeric ratios (ER) of α-HCH and o,p′-DDT ((+)-isomer concentration/(-)-isomer concentration) and o,p′-DDD (first eluting enantiomer/second enantiomer) were investigated in 112 human placentas from Finnish boys collected 1997-2001. Both o,p′-DDD and α-HCH showed changes in their ER depending on the total concentration of the compound in the sample. Their ERs are approaching a value close to racemic mixture (ER = 1) at high concentrations. At low concentrations they often differ from 1. The relationship between concentration and ER is clearly identified and it has been shown that it is not affected by analytical uncertainty. This relationship appears to be important for assessing tissue- and species-specific exposure and risk and it may indicate whether net uptake or metabolic activity is dominant in exposure for the resulting exposure of the enantiomers.

Original language	English
Pages (from-to)	390-395
Number of pages	6
Journal	Chemosphere
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.chemosphere.2005.04.100
State	Published - Jan 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chiral persistent pollutant
Enantiomeric ratio
Finland
Human exposure
Placenta

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10.1016/j.chemosphere.2005.04.100

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@article{26216be57eed434091ec883c92596f9c,

title = "Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas",

abstract = "The enantiomeric ratios (ER) of α-HCH and o,p′-DDT ((+)-isomer concentration/(-)-isomer concentration) and o,p′-DDD (first eluting enantiomer/second enantiomer) were investigated in 112 human placentas from Finnish boys collected 1997-2001. Both o,p′-DDD and α-HCH showed changes in their ER depending on the total concentration of the compound in the sample. Their ERs are approaching a value close to racemic mixture (ER = 1) at high concentrations. At low concentrations they often differ from 1. The relationship between concentration and ER is clearly identified and it has been shown that it is not affected by analytical uncertainty. This relationship appears to be important for assessing tissue- and species-specific exposure and risk and it may indicate whether net uptake or metabolic activity is dominant in exposure for the resulting exposure of the enantiomers.",

keywords = "Chiral persistent pollutant, Enantiomeric ratio, Finland, Human exposure, Placenta",

author = "Heqing Shen and Virtanen, \{H. E.\} and Main, \{Katharina M.\} and M. Kaleva and Andersson, \{A. M.\} and Skakkeb{\ae}k, \{Niels E.\} and Jorma Toppari and Schramm, \{Karl Werner\}",

note = "Funding Information: This work was supported by the European Commission (contract numbers BMH4-CT96-0314, QLK4-CT1999-01422, QLK4-CT-2001-00269 and QLK4-2002-0063). The sponsors had no part in study design, collection of data, analysis, interpretation or writing of the manuscript. The European Commission is not responsible for any use that might be made of the data appearing therein. We are grateful for the help of Terttu Vartiainen and Hannu Kiviranta (National Public Health Institute, Kuopio, Finland) for organizing the homogenization of the placentas and Dr. Kame El-Darwish (University of Turku) for checking of the English grammar.",

year = "2006",

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doi = "10.1016/j.chemosphere.2005.04.100",

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journal = "Chemosphere",

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T1 - Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas

AU - Shen, Heqing

AU - Virtanen, H. E.

AU - Main, Katharina M.

AU - Kaleva, M.

AU - Andersson, A. M.

AU - Skakkebæk, Niels E.

AU - Toppari, Jorma

AU - Schramm, Karl Werner

N1 - Funding Information: This work was supported by the European Commission (contract numbers BMH4-CT96-0314, QLK4-CT1999-01422, QLK4-CT-2001-00269 and QLK4-2002-0063). The sponsors had no part in study design, collection of data, analysis, interpretation or writing of the manuscript. The European Commission is not responsible for any use that might be made of the data appearing therein. We are grateful for the help of Terttu Vartiainen and Hannu Kiviranta (National Public Health Institute, Kuopio, Finland) for organizing the homogenization of the placentas and Dr. Kame El-Darwish (University of Turku) for checking of the English grammar.

PY - 2006/1

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N2 - The enantiomeric ratios (ER) of α-HCH and o,p′-DDT ((+)-isomer concentration/(-)-isomer concentration) and o,p′-DDD (first eluting enantiomer/second enantiomer) were investigated in 112 human placentas from Finnish boys collected 1997-2001. Both o,p′-DDD and α-HCH showed changes in their ER depending on the total concentration of the compound in the sample. Their ERs are approaching a value close to racemic mixture (ER = 1) at high concentrations. At low concentrations they often differ from 1. The relationship between concentration and ER is clearly identified and it has been shown that it is not affected by analytical uncertainty. This relationship appears to be important for assessing tissue- and species-specific exposure and risk and it may indicate whether net uptake or metabolic activity is dominant in exposure for the resulting exposure of the enantiomers.

AB - The enantiomeric ratios (ER) of α-HCH and o,p′-DDT ((+)-isomer concentration/(-)-isomer concentration) and o,p′-DDD (first eluting enantiomer/second enantiomer) were investigated in 112 human placentas from Finnish boys collected 1997-2001. Both o,p′-DDD and α-HCH showed changes in their ER depending on the total concentration of the compound in the sample. Their ERs are approaching a value close to racemic mixture (ER = 1) at high concentrations. At low concentrations they often differ from 1. The relationship between concentration and ER is clearly identified and it has been shown that it is not affected by analytical uncertainty. This relationship appears to be important for assessing tissue- and species-specific exposure and risk and it may indicate whether net uptake or metabolic activity is dominant in exposure for the resulting exposure of the enantiomers.

KW - Chiral persistent pollutant

KW - Enantiomeric ratio

KW - Finland

KW - Human exposure

KW - Placenta

UR - https://www.scopus.com/pages/publications/28544450486

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DO - 10.1016/j.chemosphere.2005.04.100

M3 - Article

C2 - 16005046

AN - SCOPUS:28544450486

SN - 0045-6535

VL - 62

SP - 390

EP - 395

JO - Chemosphere

JF - Chemosphere

IS - 3

ER -

Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas

Abstract

UN SDGs

Keywords

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