TY - JOUR
T1 - Enabling technologies towards personalization of scaffolds for large bone defect regeneration
AU - Poh, Patrina SP
AU - Lingner, Thomas
AU - Kalkhof, Stefan
AU - Märdian, Sven
AU - Baumbach, Jan
AU - Dondl, Patrick
AU - Duda, Georg N.
AU - Checa, Sara
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/4
Y1 - 2022/4
N2 - Additive manufacturing (AM) can deliver personalized scaffolds to support large volume defect tissue regeneration — a major clinical challenge in many medical disciplines. The freedom in scaffold design and composition (biomaterials and biologics) offered by AM yields a plethora of possibilities but is confronted with a heterogenous biological regeneration potential across individuals. A key challenge is to make the right choice for individualized scaffolds that match biology, anatomy, and mechanics of patients. This review provides an overview of state-of-the-art technologies, that is, in silico modelling for scaffold design, omics and bioinformatics to capture patient biology and information technology for data management, that, when combined in a synergistic way with AM, have great potential to make personalized tissue regeneration strategies available to all patients, empowering precision medicine.
AB - Additive manufacturing (AM) can deliver personalized scaffolds to support large volume defect tissue regeneration — a major clinical challenge in many medical disciplines. The freedom in scaffold design and composition (biomaterials and biologics) offered by AM yields a plethora of possibilities but is confronted with a heterogenous biological regeneration potential across individuals. A key challenge is to make the right choice for individualized scaffolds that match biology, anatomy, and mechanics of patients. This review provides an overview of state-of-the-art technologies, that is, in silico modelling for scaffold design, omics and bioinformatics to capture patient biology and information technology for data management, that, when combined in a synergistic way with AM, have great potential to make personalized tissue regeneration strategies available to all patients, empowering precision medicine.
UR - http://www.scopus.com/inward/record.url?scp=85122458337&partnerID=8YFLogxK
U2 - 10.1016/j.copbio.2021.12.002
DO - 10.1016/j.copbio.2021.12.002
M3 - Review article
C2 - 35007988
AN - SCOPUS:85122458337
SN - 0958-1669
VL - 74
SP - 263
EP - 270
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -