Enabling technologies towards personalization of scaffolds for large bone defect regeneration

Patrina SP Poh, Thomas Lingner, Stefan Kalkhof, Sven Märdian, Jan Baumbach, Patrick Dondl, Georg N. Duda, Sara Checa

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Additive manufacturing (AM) can deliver personalized scaffolds to support large volume defect tissue regeneration — a major clinical challenge in many medical disciplines. The freedom in scaffold design and composition (biomaterials and biologics) offered by AM yields a plethora of possibilities but is confronted with a heterogenous biological regeneration potential across individuals. A key challenge is to make the right choice for individualized scaffolds that match biology, anatomy, and mechanics of patients. This review provides an overview of state-of-the-art technologies, that is, in silico modelling for scaffold design, omics and bioinformatics to capture patient biology and information technology for data management, that, when combined in a synergistic way with AM, have great potential to make personalized tissue regeneration strategies available to all patients, empowering precision medicine.

Original languageEnglish
Pages (from-to)263-270
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume74
DOIs
StatePublished - Apr 2022
Externally publishedYes

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