Enabling technologies: Fermentation and downstream processing

Dirk Weuster-Botz, Dariusch Hekmat, Robert Puskeiler, Ezequiel Franco-Lara

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

27 Scopus citations

Abstract

Efficient parallel tools for bioprocess design, consequent application of the concepts for metabolic process analysis as well as innovative downstream processing techniques are enabling technologies for new industrial bioprocesses from an engineering point of view. Basic principles, state-of-the-art techniques and cutting-edge technologies are briefly reviewed. Emphasis is on parallel bioreactors for bioprocess design, biochemical systems characterization and metabolic control analysis, as well as on preparative chromatography, affinity filtration and protein crystallization on a process scale.

Original languageEnglish
Title of host publicationWhite Biotechnology
EditorsRoland Ulber, Dieter Sell, T.W. Babel, S.-O. Enfors, M. Hoare, I. Endo, A. Fiechter, W.-S. Hu, Bo Mattiasson, H. Sahm, C. Wandrey, G. Stephanopoulos, G.T. Tsao, J.-J. Zhong, J. Nielsen, K. Schuegerl, U. Stockar
Pages205-247
Number of pages43
DOIs
StatePublished - 4 Nov 2006

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
Volume105
ISSN (Print)0724-6145

Keywords

  • Affinity filtration
  • Bioprocess design
  • Enzyme kinetic models
  • Metabolic control analysis
  • Parallel bioreactors
  • Preparative chromatography
  • Protein crystallization
  • Stoichiometric network analysis

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