EMMPRIN (CD147): Ein neues schlüsselprotein in der tumorprogression des harnblasenkarzinoms

R. Nawroth; R. Stöhr; A. Hartmann; J. E. Gschwend; M. Retz

doi:10.1007/s00120-008-1828-9

EMMPRIN (CD147): Ein neues schlüsselprotein in der tumorprogression des harnblasenkarzinoms

Translated title of the contribution: EMMPRIN (CD147): A new key protein during tumor progression in bladder cancer

R. Nawroth, R. Stöhr, A. Hartmann, J. E. Gschwend, M. Retz

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

EMMPRIN (CD147) is a cell surface protein that is highly expressed on tumor cells. Elevated EMMPRIN levels have been detected in a variety of malignant tumors and have been associated with tumor progression in experimental and clinical conditions. Recent studies have shown that EMMPRIN is an independent prognostic factor for overall survival in bladder cancer patients. In a multicenter phase II trial, antibodies against EMMPRIN were shown to be successful in hepatocellular cancer therapy. We are characterizing the functional importance of EMMPRIN in bladder cancer in order to evaluate this protein as a new target molecule for therapy.

Translated title of the contribution	EMMPRIN (CD147): A new key protein during tumor progression in bladder cancer
Original language	German
Pages (from-to)	1152-1156
Number of pages	5
Journal	Urologe - Ausgabe A
Volume	47
Issue number	9
DOIs	https://doi.org/10.1007/s00120-008-1828-9
State	Published - Sep 2008
Externally published	Yes

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title = "EMMPRIN (CD147): Ein neues schl{\"u}sselprotein in der tumorprogression des harnblasenkarzinoms",

abstract = "EMMPRIN (CD147) is a cell surface protein that is highly expressed on tumor cells. Elevated EMMPRIN levels have been detected in a variety of malignant tumors and have been associated with tumor progression in experimental and clinical conditions. Recent studies have shown that EMMPRIN is an independent prognostic factor for overall survival in bladder cancer patients. In a multicenter phase II trial, antibodies against EMMPRIN were shown to be successful in hepatocellular cancer therapy. We are characterizing the functional importance of EMMPRIN in bladder cancer in order to evaluate this protein as a new target molecule for therapy.",

keywords = "EMMPRIN, MMP, Metastasis, Target molecule, Tumor progression",

author = "R. Nawroth and R. St{\"o}hr and A. Hartmann and Gschwend, {J. E.} and M. Retz",

year = "2008",

month = sep,

doi = "10.1007/s00120-008-1828-9",

language = "Deutsch",

volume = "47",

pages = "1152--1156",

journal = "Urologe - Ausgabe A",

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number = "9",

}

TY - JOUR

T1 - EMMPRIN (CD147)

T2 - Ein neues schlüsselprotein in der tumorprogression des harnblasenkarzinoms

AU - Nawroth, R.

AU - Stöhr, R.

AU - Hartmann, A.

AU - Gschwend, J. E.

AU - Retz, M.

PY - 2008/9

Y1 - 2008/9

N2 - EMMPRIN (CD147) is a cell surface protein that is highly expressed on tumor cells. Elevated EMMPRIN levels have been detected in a variety of malignant tumors and have been associated with tumor progression in experimental and clinical conditions. Recent studies have shown that EMMPRIN is an independent prognostic factor for overall survival in bladder cancer patients. In a multicenter phase II trial, antibodies against EMMPRIN were shown to be successful in hepatocellular cancer therapy. We are characterizing the functional importance of EMMPRIN in bladder cancer in order to evaluate this protein as a new target molecule for therapy.

AB - EMMPRIN (CD147) is a cell surface protein that is highly expressed on tumor cells. Elevated EMMPRIN levels have been detected in a variety of malignant tumors and have been associated with tumor progression in experimental and clinical conditions. Recent studies have shown that EMMPRIN is an independent prognostic factor for overall survival in bladder cancer patients. In a multicenter phase II trial, antibodies against EMMPRIN were shown to be successful in hepatocellular cancer therapy. We are characterizing the functional importance of EMMPRIN in bladder cancer in order to evaluate this protein as a new target molecule for therapy.

KW - EMMPRIN

KW - MMP

KW - Metastasis

KW - Target molecule

KW - Tumor progression

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U2 - 10.1007/s00120-008-1828-9

DO - 10.1007/s00120-008-1828-9

M3 - Artikel

C2 - 18688595

AN - SCOPUS:51349143014

SN - 0340-2592

VL - 47

SP - 1152

EP - 1156

JO - Urologe - Ausgabe A

JF - Urologe - Ausgabe A

IS - 9

ER -

EMMPRIN (CD147): Ein neues schlüsselprotein in der tumorprogression des harnblasenkarzinoms

Abstract

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