Elucidation of the Structure of Pharmacologically Active Magnesium L‐Aspartate Complexes

Hubert Schmidbaur, Gerhard Müller, Jürgen Riede, Gebhard Manninger, Joachim Helbig

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Magnesium therapy (infact prophylaxis, suppression of stress symptoms etc.) has proven successful on using complexes of magnesium with natural amino and polycarboxylic acids. Presumably their activity is due to formation of weak complexes, from which the magnesium is released again after transport. As has now been demonstrated, L‐aspartic acid reacts as a di‐ to tridentate ligand depending on the pH. On the basis of X‐ray crystallographic, spectroscopic and electrochemical data, a model has been designed which is consistent with medicopharmacological findings.

Original languageEnglish
Pages (from-to)1013-1014
Number of pages2
JournalAngewandte Chemie International Edition in English
Volume25
Issue number11
DOIs
StatePublished - Nov 1986
Externally publishedYes

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