Abstract
We investigated whether a connection exists between hormonal growth factors and pancreatic carcinoma. In 21 patients with advanced pancreatic cancer and 13 with other gastrointestinal neoplasms we evaluated HGH, IGF-1, IGFBP-3, thyroid hormones and the patients' survival. In patients with pancreatic cancer HGH (6.4 vs 1.8 mg/l) and IGFBP-3 (1.8 vs 1.0 mg/ml) were significantly elevated, while their survival was reduced (108.0 vs 299.7 days), the parameters showing a significant inverse correlation. HGH is elevated in advanced pancreatic cancer. The elevation is significantly correlated with a reduced patients' survival. It remains to be clarified, whether HGH is only a prognostic parameter or a pathogenetic agent.
| Original language | English |
|---|---|
| Pages (from-to) | 237-240 |
| Number of pages | 4 |
| Journal | Journal of Experimental and Clinical Cancer Research |
| Volume | 15 |
| Issue number | 3 |
| State | Published - Sep 1996 |
Keywords
- HGH
- IGF-1
- IGFBP-3
- Pancreatic cancer
- Thyroid hormones
