Abstract
Background: Y-Box-binding protein-1 (YB-1) acts as a transcription factor for multiple genes and is linked to DNA replication and repair, cell proliferation and resistance to cytostatic drugs. Patients and Methods: The prognostic value of YB-1 expression in primarily untreated malignant non-Hodgkin's lymphomas (NHLs) was examined using immunohistochemistry. Results: Expression of YB-1 was detected in 48 out of 56 NHLs, and the immunohistochemical reaction was localized exclusively in the cytoplasm. Expression of YB-1 did not correlate with clinicopathological variables. Patients with higher YB-1 expression had shorter progression-free survival during the entire period of observation (p=0.0434), as well as in the course of 30 months' observation (p=0.0253). Additionally, in the course of 50 months' observation, patients with higher expression of YB-1 demonstrated a shorter overall survival time (p=0.0383) and a shorter progression-free survival (p=0.0309). Conclusion: Elevated YB-1 expression may represent a new unfavorable prognostic factor.
| Original language | English |
|---|---|
| Pages (from-to) | 2963-2970 |
| Number of pages | 8 |
| Journal | Anticancer Research |
| Volume | 31 |
| Issue number | 9 |
| State | Published - Sep 2011 |
Keywords
- Immunohistochemistry
- Non-Hodgkin's lymphoma
- Prognosis
- YB-1
