Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma

Peter Biberthaler; Thomas Mussack; Ernst Wiedemann; Thomas Gilg; Michael Soyka; Gabi Koller; Klaus Jürgen Pfeifer; Ulrich Linsenmaier; Wolf Mutschier; Cornelia Gippner-Steppert; Marianne Jochum

doi:10.1097/00024382-200116020-00002

Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma

Peter Biberthaler
, Thomas Mussack
, Ernst Wiedemann
, Thomas Gilg
, Michael Soyka
, Gabi Koller
, Klaus Jürgen Pfeifer
, Ulrich Linsenmaier
, Wolf Mutschier
, Cornelia Gippner-Steppert
, Marianne Jochum

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Elevated systemic levels of S-100B are proposed as a potential indicator of brain damage in identifying high-risk patients after mild head trauma (MHT). Although incidence of alcohol intoxication is high in these patients, the influence of alcohol intoxication on S-100B levels is unclear. Therefore, the aim of our study was to investigate serum concentrations of S-100B in intoxicated (group 1) and sober (group 2) patients after MHT in comparison with those of mild (group 3) or severely intoxicated (group 4) individuals without trauma. S-100B was significantly increased in MHT patients exhibiting posttraumatic lesions in initial cranial computed tomography scan. Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Shock
Volume	16
Issue number	2
DOIs	https://doi.org/10.1097/00024382-200116020-00002
State	Published - Aug 2001
Externally published	Yes

Keywords

Brain damage
Cellular marker
Cerebral lesions
Glasgow coma scale
Head injury
Nerve tissue protein S-100B
Prognostic value
Screening test

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10.1097/00024382-200116020-00002

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title = "Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma",

abstract = "Elevated systemic levels of S-100B are proposed as a potential indicator of brain damage in identifying high-risk patients after mild head trauma (MHT). Although incidence of alcohol intoxication is high in these patients, the influence of alcohol intoxication on S-100B levels is unclear. Therefore, the aim of our study was to investigate serum concentrations of S-100B in intoxicated (group 1) and sober (group 2) patients after MHT in comparison with those of mild (group 3) or severely intoxicated (group 4) individuals without trauma. S-100B was significantly increased in MHT patients exhibiting posttraumatic lesions in initial cranial computed tomography scan. Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT.",

keywords = "Brain damage, Cellular marker, Cerebral lesions, Glasgow coma scale, Head injury, Nerve tissue protein S-100B, Prognostic value, Screening test",

author = "Peter Biberthaler and Thomas Mussack and Ernst Wiedemann and Thomas Gilg and Michael Soyka and Gabi Koller and Pfeifer, \{Klaus J{\"u}rgen\} and Ulrich Linsenmaier and Wolf Mutschier and Cornelia Gippner-Steppert and Marianne Jochum",

year = "2001",

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doi = "10.1097/00024382-200116020-00002",

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AU - Biberthaler, Peter

AU - Mussack, Thomas

AU - Wiedemann, Ernst

AU - Gilg, Thomas

AU - Soyka, Michael

AU - Koller, Gabi

AU - Pfeifer, Klaus Jürgen

AU - Linsenmaier, Ulrich

AU - Mutschier, Wolf

AU - Gippner-Steppert, Cornelia

AU - Jochum, Marianne

PY - 2001/8

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N2 - Elevated systemic levels of S-100B are proposed as a potential indicator of brain damage in identifying high-risk patients after mild head trauma (MHT). Although incidence of alcohol intoxication is high in these patients, the influence of alcohol intoxication on S-100B levels is unclear. Therefore, the aim of our study was to investigate serum concentrations of S-100B in intoxicated (group 1) and sober (group 2) patients after MHT in comparison with those of mild (group 3) or severely intoxicated (group 4) individuals without trauma. S-100B was significantly increased in MHT patients exhibiting posttraumatic lesions in initial cranial computed tomography scan. Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT.

AB - Elevated systemic levels of S-100B are proposed as a potential indicator of brain damage in identifying high-risk patients after mild head trauma (MHT). Although incidence of alcohol intoxication is high in these patients, the influence of alcohol intoxication on S-100B levels is unclear. Therefore, the aim of our study was to investigate serum concentrations of S-100B in intoxicated (group 1) and sober (group 2) patients after MHT in comparison with those of mild (group 3) or severely intoxicated (group 4) individuals without trauma. S-100B was significantly increased in MHT patients exhibiting posttraumatic lesions in initial cranial computed tomography scan. Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT.

KW - Brain damage

KW - Cellular marker

KW - Cerebral lesions

KW - Glasgow coma scale

KW - Head injury

KW - Nerve tissue protein S-100B

KW - Prognostic value

KW - Screening test

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DO - 10.1097/00024382-200116020-00002

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AN - SCOPUS:0035433275

SN - 1073-2322

VL - 16

SP - 97

EP - 101

JO - Shock

JF - Shock

IS - 2

ER -

Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma

Abstract

Keywords

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