Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma

Peter Biberthaler, Thomas Mussack, Ernst Wiedemann, Thomas Gilg, Michael Soyka, Gabi Koller, Klaus Jürgen Pfeifer, Ulrich Linsenmaier, Wolf Mutschier, Cornelia Gippner-Steppert, Marianne Jochum

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Elevated systemic levels of S-100B are proposed as a potential indicator of brain damage in identifying high-risk patients after mild head trauma (MHT). Although incidence of alcohol intoxication is high in these patients, the influence of alcohol intoxication on S-100B levels is unclear. Therefore, the aim of our study was to investigate serum concentrations of S-100B in intoxicated (group 1) and sober (group 2) patients after MHT in comparison with those of mild (group 3) or severely intoxicated (group 4) individuals without trauma. S-100B was significantly increased in MHT patients exhibiting posttraumatic lesions in initial cranial computed tomography scan. Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalShock
Volume16
Issue number2
DOIs
StatePublished - Aug 2001
Externally publishedYes

Keywords

  • Brain damage
  • Cellular marker
  • Cerebral lesions
  • Glasgow coma scale
  • Head injury
  • Nerve tissue protein S-100B
  • Prognostic value
  • Screening test

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