Elevated plasma endothelin concentrations in cyclosporine-treated patients after bone marrow transplantation

C. Haug, T. Duell, A. Lenich, H. J. Kolb, A. Grunert

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26 Scopus citations

Abstract

Administration of cyclosporine is often associated with the development of renal dysfunction and hypertension. Since recent data from animal experiments provide evidence that endothelin, a potent vasoconstrictive peptide, might play a role in mediating cyclosporine-related renal and cardiovascular side-effects, the present study was designed to investigate whether plasma endothelin concentrations are elevated in cyclosporine-treated patients. Plasma endothelin concentrations, determined by radioimmunoassay after Sep Pak C18 extraction, were significantly elevated in cyclosporine-treated patients after bone marrow transplantation (8.3 ± 1.4 ng/l, n = 28) compared to patients not treated with cyclosporine after bone marrow transplantation (3.9 ± 0.2(*) ng/l, n = 11), patients with haematological disorders (3.9 ± 0.3(**) ng/l, n = 11) not treated with bone marrow transplantation and to normal control subjects (3.1 ± 0.2(***) ng/l, n = 33) ((*)P < 0.05, (**)P < 0.01, (***)P < 0.001). Furthermore, plasma endothelin levels exhibited a significant correlation with cyclosporine concentrations (r = 0.57, P < 0.01). The present data, demonstrating elevated plasma endothelin concentrations in cyclosporine-treated patients, suggest that the cyclosporine-associated renal and cardiovascular side-effects might in part be mediated by cyclosporine-induced stimulation of endothelin release.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalBone Marrow Transplantation
Volume16
Issue number1
StatePublished - 1995
Externally publishedYes

Keywords

  • Bone marrow transplantation
  • Cyclosporine
  • Endothelin

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