Elevated inflammatory laboratory parameters in spontaneous cervical artery dissection as compared to traumatic dissection: A retrospective case-control study

K. Forster, H. Poppert, B. Conrad, D. Sander

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Several studies have reported infection as a possible risk factor for cervical artery dissection (CAD). We retrospectively analyzed several inflammatory parameters of CAD patients with the aim of detecting differences between spontaneous (n = 25) and traumatic (n = 18) CAD. In this case-control study, we observed significantly higher absolute leucocyte values (10.3 versus 8.1 G/L; p = 0.02) as well as an elevated frequency of leucocytosis (64% versus 28%; p = 0.02) and elevated CRP (60% versus 28%; p = 0.04) in patients without a history of trauma ("spontaneous" CAD) compared with patients with traumarelated CAD. As the elevated inflammatory laboratory parameters were not associated with an elevated infection rate, these findings imply a role of an acute inflammation as a pathogenetic factor in spontaneous CAD. The cause and mechanism of the inflammatory process remain unknown.

Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalJournal of Neurology
Volume253
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • Dissection
  • Inflammation
  • Leucocytosis
  • Trauma

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