Elevated C-reactive protein is associated with an increased intima to media thickness of the common carotid artery

Kerstin Winbeck; Christian Kukla; Holger Poppert; Jürgen Klingelhöfer; Bastian Conrad; Dirk Sander

doi:10.1159/000047747

Elevated C-reactive protein is associated with an increased intima to media thickness of the common carotid artery

Kerstin Winbeck, Christian Kukla, Holger Poppert, Jürgen Klingelhöfer, Bastian Conrad, Dirk Sander

Default

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

In this study, we analyzed the relationship between serum C-reactive protein (CRP) and the intima to media thickness (IMT) of the common carotid artery in 411 consecutive neurological inpatients (215 males, mean age 64.1 years). The CRP concentration was determined within 12 h and patients were subdivided according to the CRP level. Patients with an elevated CRP (n = 149) showed a significantly larger IMT [1.05 mm (95% confidence interval (CI) 1.02-1.09) vs. 0.92 mm (95% CI 0.89-0.94)]. Multivariate linear regression analysis revealed that an elevated CRP level, age, pack-years of smoking, body mass index, incidence of diabetes mellitus and ischemic stroke were independently associated with an increased IMT (p < 0.05).

Original language	English
Pages (from-to)	57-63
Number of pages	7
Journal	Cerebrovascular Diseases
Volume	13
Issue number	1
DOIs	https://doi.org/10.1159/000047747
State	Published - 2002

Keywords

Atherosclerosis
C-reactive protein
Chronic inflammation
Duplex sonography
Intima to media thickness

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000047747

Cite this

@article{67d3101944d245208637451063539355,

title = "Elevated C-reactive protein is associated with an increased intima to media thickness of the common carotid artery",

abstract = "In this study, we analyzed the relationship between serum C-reactive protein (CRP) and the intima to media thickness (IMT) of the common carotid artery in 411 consecutive neurological inpatients (215 males, mean age 64.1 years). The CRP concentration was determined within 12 h and patients were subdivided according to the CRP level. Patients with an elevated CRP (n = 149) showed a significantly larger IMT [1.05 mm (95% confidence interval (CI) 1.02-1.09) vs. 0.92 mm (95% CI 0.89-0.94)]. Multivariate linear regression analysis revealed that an elevated CRP level, age, pack-years of smoking, body mass index, incidence of diabetes mellitus and ischemic stroke were independently associated with an increased IMT (p < 0.05).",

keywords = "Atherosclerosis, C-reactive protein, Chronic inflammation, Duplex sonography, Intima to media thickness",

author = "Kerstin Winbeck and Christian Kukla and Holger Poppert and J{\"u}rgen Klingelh{\"o}fer and Bastian Conrad and Dirk Sander",

year = "2002",

doi = "10.1159/000047747",

language = "English",

volume = "13",

pages = "57--63",

journal = "Cerebrovascular Diseases",

issn = "1015-9770",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Elevated C-reactive protein is associated with an increased intima to media thickness of the common carotid artery

AU - Winbeck, Kerstin

AU - Kukla, Christian

AU - Poppert, Holger

AU - Klingelhöfer, Jürgen

AU - Conrad, Bastian

AU - Sander, Dirk

PY - 2002

Y1 - 2002

N2 - In this study, we analyzed the relationship between serum C-reactive protein (CRP) and the intima to media thickness (IMT) of the common carotid artery in 411 consecutive neurological inpatients (215 males, mean age 64.1 years). The CRP concentration was determined within 12 h and patients were subdivided according to the CRP level. Patients with an elevated CRP (n = 149) showed a significantly larger IMT [1.05 mm (95% confidence interval (CI) 1.02-1.09) vs. 0.92 mm (95% CI 0.89-0.94)]. Multivariate linear regression analysis revealed that an elevated CRP level, age, pack-years of smoking, body mass index, incidence of diabetes mellitus and ischemic stroke were independently associated with an increased IMT (p < 0.05).

AB - In this study, we analyzed the relationship between serum C-reactive protein (CRP) and the intima to media thickness (IMT) of the common carotid artery in 411 consecutive neurological inpatients (215 males, mean age 64.1 years). The CRP concentration was determined within 12 h and patients were subdivided according to the CRP level. Patients with an elevated CRP (n = 149) showed a significantly larger IMT [1.05 mm (95% confidence interval (CI) 1.02-1.09) vs. 0.92 mm (95% CI 0.89-0.94)]. Multivariate linear regression analysis revealed that an elevated CRP level, age, pack-years of smoking, body mass index, incidence of diabetes mellitus and ischemic stroke were independently associated with an increased IMT (p < 0.05).

KW - Atherosclerosis

KW - C-reactive protein

KW - Chronic inflammation

KW - Duplex sonography

KW - Intima to media thickness

UR - http://www.scopus.com/inward/record.url?scp=0036159630&partnerID=8YFLogxK

U2 - 10.1159/000047747

DO - 10.1159/000047747

M3 - Article

C2 - 11810012

AN - SCOPUS:0036159630

SN - 1015-9770

VL - 13

SP - 57

EP - 63

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

IS - 1

ER -

Elevated C-reactive protein is associated with an increased intima to media thickness of the common carotid artery

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this