@inproceedings{297808f19467448b81435168a09b4c30,
title = "Electrochemical microfluidic biosensor for the protein-based quantification of β-lactams",
abstract = "In this work, we present a novel approach for the point-of-care testing (POCT) of β-lactam antibiotics on a miniaturized electrochemical microfluidic platform. Herein, a highly sensitive, lowcost and versatile biosensor is combined with an enzyme linked assay (ELA) using the penicillin binding protein 3 (PBP-3) for the fast and facile detection of s-lactams from very low sample volumes (580 nl). The demonstration of the system applicability is successfully shown by measuring different piperacillin concentrations in spiked human blood plasma with an inter-assay coefficient of variation (CV) below 15 % and a limit of detection (LOD) of 8.34 ng ml-1.",
keywords = "Antibiotics, Electrochemical biosensor, Penicillin binding protein 3, Point-of-care",
author = "R. Bruch and C. Chatelle and A. Kling and C. Dincer and W. Weber and G. Urban",
year = "2016",
language = "English",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "1667--1668",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
note = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
}