Electrocardiographic and cardiac autonomic indices - Implications of sex-specific risk stratification in women after acute myocardial infarction

Romy Ubrich, Petra Barthel, Anna Berkefeld, Katerina Hnatkova, Katharina M. Huster, Michael Dommasch, Daniel Sinnecker, Alexander Steger, Georg Schmidt, Marek Malik

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Background: The debate on whether sex-specific predictive models improve risk stratification after myocardial infarction is ongoing. Methods: This review summarises the current clinical knowledge on sex-specific differences in post-infarction risk stratification parameters. Particular focus is given to electrocardiographic risk factors and indices of cardiac autonomic status. Results: Differences in the underlying pathophysiology between men and women are known. However, clinical findings often lead to uncertain conclusions for a number of risk predictors including, among others, resting heart rate, heart rate variability, heart rate turbulence, QT interval duration, and QRS-T angle. The review links recent findings in prognostic parameters with successful approaches in sex-specific non-invasive risk stratification. Conclusion: Disparities are described in the current clinical opinions on the relevance of investigated parameters in women and possible directions for further research in the field are given.

Original languageEnglish
Pages (from-to)3817-3828
Number of pages12
JournalCurrent Pharmaceutical Design
Volume22
Issue number25
DOIs
StatePublished - 1 Jul 2016

Keywords

  • AMI
  • Baroreflex sensitivity
  • Heart rate
  • Heart rate turbulence
  • Heart rate variability
  • QRS T-angle
  • QT width
  • Women

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