TY - GEN
T1 - Electrical stimulation in the cochlea
T2 - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
AU - Bai, Siwei
AU - Croner, Albert
AU - Encke, Jorg
AU - Hemmert, Werner
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/7
Y1 - 2020/7
N2 - Existing computational studies of cochlear implants have demonstrated that the structural detail of threedimensional (3D) cochlear models exerts influence on the current spread within the cochlea. Nevertheless, the significance of including the microstructures inside the modiolar bone in a cochlear model is still unclear in the literature. We employed two different multi-compartment neuron models to simulate auditory nerve fibres, and compared response characteristics of the fibre population between a detailed and a simplified 3D cochlear model. Results showed that although the prediction of firing is dependent on the details of the neuron model, the responses of the fibre population to the electrical stimulus, especially the location of the initiation of action potential, varied between the detailed and the simplified models. Therefore, the inclusion of the modiolar microstructures in a cochlear model may be necessary for fully understanding the firing of auditory nerve fibres.
AB - Existing computational studies of cochlear implants have demonstrated that the structural detail of threedimensional (3D) cochlear models exerts influence on the current spread within the cochlea. Nevertheless, the significance of including the microstructures inside the modiolar bone in a cochlear model is still unclear in the literature. We employed two different multi-compartment neuron models to simulate auditory nerve fibres, and compared response characteristics of the fibre population between a detailed and a simplified 3D cochlear model. Results showed that although the prediction of firing is dependent on the details of the neuron model, the responses of the fibre population to the electrical stimulus, especially the location of the initiation of action potential, varied between the detailed and the simplified models. Therefore, the inclusion of the modiolar microstructures in a cochlear model may be necessary for fully understanding the firing of auditory nerve fibres.
UR - http://www.scopus.com/inward/record.url?scp=85091001929&partnerID=8YFLogxK
U2 - 10.1109/EMBC44109.2020.9175933
DO - 10.1109/EMBC44109.2020.9175933
M3 - Conference contribution
AN - SCOPUS:85091001929
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 2324
EP - 2327
BT - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 20 July 2020 through 24 July 2020
ER -