Electrical manipulation of DNA on metal surfaces

Marc Tornow; Kenji Arinaga; Ulrich Rant

doi:10.1007/978-1-59745-218-2_9

Electrical manipulation of DNA on metal surfaces

Marc Tornow, Kenji Arinaga, Ulrich Rant

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

We review recent work on the active manipulation of DNA on metal substrates by electric fields. This includes the controlled positioning, alignment, or release of DNA on or into dedicated locations and the control of hybridization. In this context, we discuss techniques for immobilizing DNA on metal surfaces and methods of characterizing such hybrid systems. In particular, we focus on electrically induced, conformational changes of monolayers of short oligonucleotides on gold substrates. Such switchable layers allow for molecular dynamics studies at interfaces and have demonstrated large potential in label-free biosensing applications.

Original language	English
Title of host publication	NanoBioTechnology
Subtitle of host publication	BioInspired Devices and Materials of the Future
Publisher	Humana Press
Pages	187-214
Number of pages	28
ISBN (Print)	9781588298942
DOIs	https://doi.org/10.1007/978-1-59745-218-2_9
State	Published - 2008
Externally published	Yes

Keywords

Biomolecular films
DNA-basedsensing
biosensors
conformational changes
molecular dynamics
nano-electromechanical system (NEMS)
oligonucleotides
self-assembled monolayers
surface functionalization
switchable layer

Access to Document

10.1007/978-1-59745-218-2_9

Cite this

@inbook{d48a5a06456541108df7a9d89e0eef73,

title = "Electrical manipulation of DNA on metal surfaces",

abstract = "We review recent work on the active manipulation of DNA on metal substrates by electric fields. This includes the controlled positioning, alignment, or release of DNA on or into dedicated locations and the control of hybridization. In this context, we discuss techniques for immobilizing DNA on metal surfaces and methods of characterizing such hybrid systems. In particular, we focus on electrically induced, conformational changes of monolayers of short oligonucleotides on gold substrates. Such switchable layers allow for molecular dynamics studies at interfaces and have demonstrated large potential in label-free biosensing applications.",

keywords = "Biomolecular films, DNA-basedsensing, biosensors, conformational changes, molecular dynamics, nano-electromechanical system (NEMS), oligonucleotides, self-assembled monolayers, surface functionalization, switchable layer",

author = "Marc Tornow and Kenji Arinaga and Ulrich Rant",

year = "2008",

doi = "10.1007/978-1-59745-218-2_9",

language = "English",

isbn = "9781588298942",

pages = "187--214",

booktitle = "NanoBioTechnology",

publisher = "Humana Press",

}

TY - CHAP

T1 - Electrical manipulation of DNA on metal surfaces

AU - Tornow, Marc

AU - Arinaga, Kenji

AU - Rant, Ulrich

PY - 2008

Y1 - 2008

N2 - We review recent work on the active manipulation of DNA on metal substrates by electric fields. This includes the controlled positioning, alignment, or release of DNA on or into dedicated locations and the control of hybridization. In this context, we discuss techniques for immobilizing DNA on metal surfaces and methods of characterizing such hybrid systems. In particular, we focus on electrically induced, conformational changes of monolayers of short oligonucleotides on gold substrates. Such switchable layers allow for molecular dynamics studies at interfaces and have demonstrated large potential in label-free biosensing applications.

AB - We review recent work on the active manipulation of DNA on metal substrates by electric fields. This includes the controlled positioning, alignment, or release of DNA on or into dedicated locations and the control of hybridization. In this context, we discuss techniques for immobilizing DNA on metal surfaces and methods of characterizing such hybrid systems. In particular, we focus on electrically induced, conformational changes of monolayers of short oligonucleotides on gold substrates. Such switchable layers allow for molecular dynamics studies at interfaces and have demonstrated large potential in label-free biosensing applications.

KW - Biomolecular films

KW - DNA-basedsensing

KW - biosensors

KW - conformational changes

KW - molecular dynamics

KW - nano-electromechanical system (NEMS)

KW - oligonucleotides

KW - self-assembled monolayers

KW - surface functionalization

KW - switchable layer

UR - http://www.scopus.com/inward/record.url?scp=67849094582&partnerID=8YFLogxK

U2 - 10.1007/978-1-59745-218-2_9

DO - 10.1007/978-1-59745-218-2_9

M3 - Chapter

AN - SCOPUS:67849094582

SN - 9781588298942

SP - 187

EP - 214

BT - NanoBioTechnology

PB - Humana Press

ER -

Electrical manipulation of DNA on metal surfaces

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this