EJE Prize 2023: genes on steroids-genomic control of hepatic metabolism by the glucocorticoid receptor

Fabiana Quagliarini, Konstantinos Makris, Marika E. Friano, Nina Henriette Uhlenhaut

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Glucocorticoids are essential hormones produced by the adrenal cortex with prominent circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis through coordinated activities that control the major pathways of energy metabolism. Glucocorticoids activate the glucocorticoid receptor (GR), a nuclear hormone receptor that regulates the transcription of hundreds of genes in response to ligand. This review aims to provide a comprehensive overview of glucocorticoid receptor signaling impact on glucose, amino acid, and lipid metabolism in the liver. We integrate fundamental and current findings elucidating key GR-regulated pathways from a physiologic, biochemical, and molecular point-of-view. Here, we focus on the transcriptional regulation of well-characterized hepatic GR target genes, and on those GR co-factors that coordinate nutritional and hormonal signals.

Original languageEnglish
Pages (from-to)R111-R130
JournalEuropean Journal of Endocrinology
Volume188
Issue number5
DOIs
StatePublished - May 2023

Keywords

  • glucocorticoid receptor
  • hormones
  • liver metabolism
  • transcription

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