Einschränkung der myokardialen perfusions-reserve bei mikrovaskular-angina (syndrom X): Nachweis durch ^99mTc-MIBI-SPECT

Aim: In 22 patients with typical chest pain and normal coronary arteries (microvascular angina, syndrome X) ^99mTc-MIBI-SPECT was examined in regard to assess impairment of myocardial perfusion reserve Method: The study was performed with ^99mTc-MIBI-SPECT at rest and under vasodilation with dipyndamole. The findings were compared with a normal database A normal perfusion reserve was said to be an increase >20% of the ^99mTc-MIBI-activity. Results: In 2/22 (9%) of the patients the perfusion reserve lay >20% i.e. 37%. In 91% of the patients a diminution or even decrease of the perfusion was to be seen From these 9/22 (41 %) of the patients showed a diminution of the ^99mTc-MIBI-uptake by 6% 11/22 patients had a decrease of the perfusion under vasodilation with dipyridamole i.e a lower activity of 99mTc-MIBI by 13%. Conclusion: Vasodilation ^99mTc-MIBI-SPECT offers good imaging quality and enables semiquantitative assessment of myocardial perfusion reserve in patients with microvascular angina.