Einsatzmöglichkeiten der Positronen-Emissions-Tomographie beim Mammakarzinom

Translated title of the contribution: Clinical Applications of Positron Emission Tomography in Breast Cancer Patients

W. Römer, N. Avril, M. Schwaiger

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Increased glucose metabolism by malignant tissue can be visualized with positron emission tomography (PET), using the radiolabeled glucose analogue F-18 fluorodeoxyglucose (FDG). Depending on the criteria of image interpretation FDG-PET allows detection of breast cancer with a sensitivity of 68% to 94% and a specificity of 84% to 97%. However, sensitivity to visualize small tumors (< 1 cm) is limited. Positron emission tomography demonstrates tumor involvement of regional lymph nodes with high accuracy, predominantly in patients with advanced breast cancer. The sensitivity for the detection of axillary lymph node metastases was 79% with a corresponding specificity of 96%. Lymph node metastases could not be identified in four of six patients with small primary breast cancer (stage pT1), resulting in a sensitivity of only 33% in these patients. By visualizing primary tumors and metastases in one imaging procedure. PET imaging may allow the effective staging of breast cancer patients. Further studies are needed to define the role of scintigraphic techniques for the diagnostic work-up in patients.

Translated title of the contributionClinical Applications of Positron Emission Tomography in Breast Cancer Patients
Original languageGerman
Pages (from-to)60-62
Number of pages3
JournalActa Medica Austriaca
Volume24
Issue number2
StatePublished - 1997
Externally publishedYes

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