Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA): Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland

I. Brockow; A. Zutavern; K. Franke; B. Schaaf; A. Von Berg; U. Krämer; I. Lehmann; O. Herbarth; M. Borte; A. Grübl; C. P. Bauer; H. E. Wichmann; J. Heinrich

doi:10.1007/s00112-007-1527-4

Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA): Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland

Translated title of the contribution: Influences of lifestyle-related factors on the immune system and the development of allergies in childhood (LISA): Design and results to date of a prospective birth cohort study

I. Brockow, A. Zutavern, K. Franke, B. Schaaf, A. Von Berg, U. Krämer, I. Lehmann, O. Herbarth, M. Borte, A. Grübl, C. P. Bauer, H. E. Wichmann, J. Heinrich

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background. The frequency of allergic diseases shortly after reunification differed between East- and West Germany. Design. In this prospective birth cohort study, 3,097 newborns were recruited in Munich, Leipzig and the Rhineland in 1998. Questionnaires, house dust and volatile organic compound (VOC) analyses, as well as blood tests, allowed to associate lifestyle related factors with immune parameters and the onset of atopic diseases. Results. The frequency of atopic eczema (AE) differed significantly between the study centers. Solid food introduction past the sixth month had no influence on the development of an AE. Exposure to high concentrations of endotoxin in house dust early in life might protect against the development of an allergic immune response whereas exposure to allergens and indoor air chemicals changed the immune reactivity in the direction of an increased atopic risk. Conclusions. The LISA study will help to identify associations between different lifestyle related factors and parameters of the immune system and atopic diseases.

Translated title of the contribution	Influences of lifestyle-related factors on the immune system and the development of allergies in childhood (LISA): Design and results to date of a prospective birth cohort study
Original language	German
Pages (from-to)	249-255
Number of pages	7
Journal	Monatsschrift fur Kinderheilkunde
Volume	156
Issue number	3
DOIs	https://doi.org/10.1007/s00112-007-1527-4
State	Published - Mar 2008

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Brockow, I., Zutavern, A., Franke, K., Schaaf, B., Von Berg, A., Krämer, U., Lehmann, I., Herbarth, O., Borte, M., Grübl, A., Bauer, C. P., Wichmann, H. E., & Heinrich, J. (2008). Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA): Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland. Monatsschrift fur Kinderheilkunde, 156(3), 249-255. https://doi.org/10.1007/s00112-007-1527-4

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title = "Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA): Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland",

abstract = "Background. The frequency of allergic diseases shortly after reunification differed between East- and West Germany. Design. In this prospective birth cohort study, 3,097 newborns were recruited in Munich, Leipzig and the Rhineland in 1998. Questionnaires, house dust and volatile organic compound (VOC) analyses, as well as blood tests, allowed to associate lifestyle related factors with immune parameters and the onset of atopic diseases. Results. The frequency of atopic eczema (AE) differed significantly between the study centers. Solid food introduction past the sixth month had no influence on the development of an AE. Exposure to high concentrations of endotoxin in house dust early in life might protect against the development of an allergic immune response whereas exposure to allergens and indoor air chemicals changed the immune reactivity in the direction of an increased atopic risk. Conclusions. The LISA study will help to identify associations between different lifestyle related factors and parameters of the immune system and atopic diseases.",

keywords = "Allergy, East-West differences, Environmental factors, Immune system, Lifestyle",

author = "I. Brockow and A. Zutavern and K. Franke and B. Schaaf and {Von Berg}, A. and U. Kr{\"a}mer and I. Lehmann and O. Herbarth and M. Borte and A. Gr{\"u}bl and Bauer, {C. P.} and Wichmann, {H. E.} and J. Heinrich",

year = "2008",

month = mar,

doi = "10.1007/s00112-007-1527-4",

language = "Deutsch",

volume = "156",

pages = "249--255",

journal = "Monatsschrift fur Kinderheilkunde",

issn = "0026-9298",

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Brockow, I, Zutavern, A, Franke, K, Schaaf, B, Von Berg, A, Krämer, U, Lehmann, I, Herbarth, O, Borte, M, Grübl, A, Bauer, CP, Wichmann, HE & Heinrich, J 2008, 'Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA): Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland', Monatsschrift fur Kinderheilkunde, vol. 156, no. 3, pp. 249-255. https://doi.org/10.1007/s00112-007-1527-4

Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA): Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland. / Brockow, I.; Zutavern, A.; Franke, K. et al.
In: Monatsschrift fur Kinderheilkunde, Vol. 156, No. 3, 03.2008, p. 249-255.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA)

T2 - Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland

AU - Brockow, I.

AU - Zutavern, A.

AU - Franke, K.

AU - Schaaf, B.

AU - Von Berg, A.

AU - Krämer, U.

AU - Lehmann, I.

AU - Herbarth, O.

AU - Borte, M.

AU - Grübl, A.

AU - Bauer, C. P.

AU - Wichmann, H. E.

AU - Heinrich, J.

PY - 2008/3

Y1 - 2008/3

N2 - Background. The frequency of allergic diseases shortly after reunification differed between East- and West Germany. Design. In this prospective birth cohort study, 3,097 newborns were recruited in Munich, Leipzig and the Rhineland in 1998. Questionnaires, house dust and volatile organic compound (VOC) analyses, as well as blood tests, allowed to associate lifestyle related factors with immune parameters and the onset of atopic diseases. Results. The frequency of atopic eczema (AE) differed significantly between the study centers. Solid food introduction past the sixth month had no influence on the development of an AE. Exposure to high concentrations of endotoxin in house dust early in life might protect against the development of an allergic immune response whereas exposure to allergens and indoor air chemicals changed the immune reactivity in the direction of an increased atopic risk. Conclusions. The LISA study will help to identify associations between different lifestyle related factors and parameters of the immune system and atopic diseases.

AB - Background. The frequency of allergic diseases shortly after reunification differed between East- and West Germany. Design. In this prospective birth cohort study, 3,097 newborns were recruited in Munich, Leipzig and the Rhineland in 1998. Questionnaires, house dust and volatile organic compound (VOC) analyses, as well as blood tests, allowed to associate lifestyle related factors with immune parameters and the onset of atopic diseases. Results. The frequency of atopic eczema (AE) differed significantly between the study centers. Solid food introduction past the sixth month had no influence on the development of an AE. Exposure to high concentrations of endotoxin in house dust early in life might protect against the development of an allergic immune response whereas exposure to allergens and indoor air chemicals changed the immune reactivity in the direction of an increased atopic risk. Conclusions. The LISA study will help to identify associations between different lifestyle related factors and parameters of the immune system and atopic diseases.

KW - Allergy

KW - East-West differences

KW - Environmental factors

KW - Immune system

KW - Lifestyle

UR - http://www.scopus.com/inward/record.url?scp=40949092671&partnerID=8YFLogxK

U2 - 10.1007/s00112-007-1527-4

DO - 10.1007/s00112-007-1527-4

M3 - Artikel

AN - SCOPUS:40949092671

SN - 0026-9298

VL - 156

SP - 249

EP - 255

JO - Monatsschrift fur Kinderheilkunde

JF - Monatsschrift fur Kinderheilkunde

IS - 3

ER -

Brockow I, Zutavern A, Franke K, Schaaf B, Von Berg A, Krämer U et al. Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA): Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland. Monatsschrift fur Kinderheilkunde. 2008 Mar;156(3):249-255. doi: 10.1007/s00112-007-1527-4

Einfluss von lebensbedingungen und verhaltensweisen auf die entwicklung von immunsystem und allergien im ost-west-vergleich (LISA): Design und bisherige ergebnisse einer prospektiven geburtskohortenstudie in Deutschland

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