Ein neues Verfahren zur positionsselektiven Einführung von Trifluormethylgruppen in Heteroaromaten: Synthese von 3‐Trifluormethylfuranen

A New Method for Selective Introduction of Trifluoromethyl Groups into Heteroaromatic Compounds. Synthesis of Trifluoromethylfurans Transformation of 4,4‐bis(trifluoromethyl)‐1‐oxabuta‐1,3‐dienes (2) into 2‐fluoro‐3‐trifluoromethylfurans (4) can be achieved in a two step procedure by treatment with tin (II) chloride and sodium hydride. The fluorine atom at skeleton position 2 is replaced smoothly by various nucleophiles. The reaction sequence represents a preparatively simple method for the selective introduction of biologically relevant substituents into 3‐trifluoromethylfurans.