Abstract
Biocompatible ionic liquids act as a substrate reservoir and an in situ extracting agent in biotransformations with whole cells (see scheme). In the reduction of 4-chloroacetophenone to (R)-1-(4-chlorophenyl)ethanol, high product concentration (82 g L-1) and purity (99.6% ee) were achieved without the addition of cofactors and without damaging the biocatalyst.
Original language | English |
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Pages (from-to) | 4529-4531 |
Number of pages | 3 |
Journal | Angewandte Chemie International Edition in English |
Volume | 43 |
Issue number | 34 |
DOIs | |
State | Published - 27 Aug 2004 |
Keywords
- Asymmetric catalysis
- Biotransformations
- Cofactors
- Ionic liquidswhole-cell methods