Efficient whole-cell biotransformation in a biphasic ionic liquid/water system

Holger Pfruender, Maya Amidjojo, Udo Kragl, Dirk Weuster-Botz

Research output: Contribution to journalArticlepeer-review

167 Scopus citations

Abstract

Biocompatible ionic liquids act as a substrate reservoir and an in situ extracting agent in biotransformations with whole cells (see scheme). In the reduction of 4-chloroacetophenone to (R)-1-(4-chlorophenyl)ethanol, high product concentration (82 g L-1) and purity (99.6% ee) were achieved without the addition of cofactors and without damaging the biocatalyst.

Original languageEnglish
Pages (from-to)4529-4531
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume43
Issue number34
DOIs
StatePublished - 27 Aug 2004

Keywords

  • Asymmetric catalysis
  • Biotransformations
  • Cofactors
  • Ionic liquidswhole-cell methods

Fingerprint

Dive into the research topics of 'Efficient whole-cell biotransformation in a biphasic ionic liquid/water system'. Together they form a unique fingerprint.

Cite this