Efficient synthesis of biologically interesting 3,4-diaryl-substituted succinimides and maleimides: Application of iron-catalyzed carbonylations

Saisuree Prateeptongkum, Katrin Marie Driller, Ralf Jackstell, Anke Spannenberg, Matthias Beller

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A straightforward two-step synthesis of trans-3,4-disubstituted succin imides through a palladium-catalyzed Sonogashira reaction and an iron-catalyzed double carbonylation is described. In situ oxidative dehydrogenation gave the corresponding 3,4-diarylmaleimides. By starting from readily available aryl and hetgeroaryl halides, a variety of new analogues and derivatives of bioactive 3,4-bisindolylmaleimides are obtained in good yield and selectivity.

Original languageEnglish
Pages (from-to)9606-9615
Number of pages10
JournalChemistry - A European Journal
Volume16
Issue number31
DOIs
StatePublished - 16 Aug 2010
Externally publishedYes

Keywords

  • Carbonylation
  • Iron
  • Maleimides
  • Reaction
  • Sonogashira
  • Succinimides

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