Efficient palladium-catalyzed double carbonylation of o-dibromobenzenes: Synthesis of thalidomide

Jianbin Chen, Kishore Natte, Anke Spannenberg, Helfried Neumann, Matthias Beller, Xiao Feng Wu

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

We describe here a convenient and mild procedure for double carbonylation of o-dibromobenzenes with various 2-amino pyridines and naturally occurring amines, thus providing in good to excellent yields N-substituted phthalimides by using this palladium-catalyzed carbonylation procedure. Furthermore, for the first time we have applied the developed synthetic protocol for the synthesis of biologically active molecule thalidomide via a single step carbonylative cyclization reaction in excellent yield.

Original languageEnglish
Pages (from-to)5578-5581
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number30
DOIs
StatePublished - 14 Aug 2014
Externally publishedYes

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