Efficient one-pot synthesis of substituted 1-acylaminocyclohex-2-enes

Sandra Hübner, Helfried Neumann, Axel Jacobi Wangelin, Stefan Klaus, Dirk Strübing, Holger Klein, Matthias Beller

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Substituted 1-acylaminocyclohex-2-enes can be prepared in good to excellent yields by multicomponent reactions (MCR) utilizing ubiquitously available aldehydes, amides, and dienophiles (AAD reaction). This novel one-pot reaction involves 1-acylaminobuta-1,3-dienes as key intermediates, which undergo subsequent Diels-Alder reactions.

Original languageEnglish
Pages (from-to)2084-2089
Number of pages6
Issue number12
StatePublished - 1 Aug 2005
Externally publishedYes


  • Aldehydes
  • Cyclohexenes
  • Diels-Alder reaction
  • Dienamides
  • Multicomponent reactions


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