Abstract
Most studies regarding the effectiveness of percutaneous transluminal angioplasty of femoropopliteal stenoses merely regard the macrocirculation. Microvascular dysfunktion within the scope of interventional therapy is hardly considered. Indeed, a significant decrease of the transcutaneous partial pressure of oxygen (tcpO2) is reported in studies. However, there is disagreement about the underlying causes, as well as about clinical consequences. Hence, the purpose of this study was the analysis of the effectiveness of an additional PGE1 medication during angioplasty concerning the improvement of the oxygen supply of the tissue. The intervention-related decrease of the transcutaneous partial pressure of oxygen can be avoided by the application of an additional therapy with Alprostadil. Even four weeks after intervention, a significant increase of tcpO2 values can be detected. Present follow-up evaluations demonstrate that an additional PGE1 therapy improves the effectiveness of the intervention sustainably.
| Translated title of the contribution | Effects of additional PGE-1 medication during PTA on the microcirculation of the extremities |
|---|---|
| Original language | German |
| Pages (from-to) | 85-87 |
| Number of pages | 3 |
| Journal | Vasomed |
| Volume | 19 |
| Issue number | 2 |
| State | Published - Apr 2007 |