TY - JOUR
T1 - Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man
AU - Schulte-Frohlinde, Ewert
AU - Reindl, Wolfgang
AU - Bierling, Daniela
AU - Lersch, Christian
AU - Brantl, Victor
AU - Teschemacher, Hansjörg
AU - Schusdziarra, Volker
PY - 2000/3
Y1 - 2000/3
N2 - Food-derived opioid peptides such as β-casomorphins are of interest for treatment of chronic diarrhea. The β-casomorphin analog casokefamide was administered orally at doses of 5.5, 8.0, and 16.0 mg to 10 healthy male volunteers, respectively. Dose-dependent increases of plasma levels with a maximum of 350 fmol/l were determined. No side-effects due to casokefamide has been observed. In comparison to placebo, casokefamide showed a trend toward prolongation of oro-caecal transit time. Orally applied casokefamide is well tolerated and may represent a useful tool for treatment of diarrhea in the future. (C) 2000 Elsevier Science Inc.
AB - Food-derived opioid peptides such as β-casomorphins are of interest for treatment of chronic diarrhea. The β-casomorphin analog casokefamide was administered orally at doses of 5.5, 8.0, and 16.0 mg to 10 healthy male volunteers, respectively. Dose-dependent increases of plasma levels with a maximum of 350 fmol/l were determined. No side-effects due to casokefamide has been observed. In comparison to placebo, casokefamide showed a trend toward prolongation of oro-caecal transit time. Orally applied casokefamide is well tolerated and may represent a useful tool for treatment of diarrhea in the future. (C) 2000 Elsevier Science Inc.
KW - Casokefamide
KW - Human study
KW - Motility
KW - Opioid peptides
KW - Plasma levels
KW - β-Casomorphin
UR - http://www.scopus.com/inward/record.url?scp=0033996761&partnerID=8YFLogxK
U2 - 10.1016/S0196-9781(00)00166-2
DO - 10.1016/S0196-9781(00)00166-2
M3 - Article
C2 - 10793229
AN - SCOPUS:0033996761
SN - 0196-9781
VL - 21
SP - 439
EP - 442
JO - Peptides
JF - Peptides
IS - 3
ER -
