Effects of ENU dosage on mouse strains

Monica J. Justice, Don A. Carpenter, Jack Favor, Angelika Neuhauser-Klaus, Martin Hrabé De Angelis, Dian Soewarto, Amy Moser, Sabine Cordes, Darla Miller, Verne Chapman, John S. Weber, Eugene M. Rinchik, Patricia R. Hunsicker, William L. Russell, Vernon C. Bode

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F1 hybrids to ENU. The results show that most F1 hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.

Original languageEnglish
Pages (from-to)484-488
Number of pages5
JournalMammalian Genome
Volume11
Issue number7
DOIs
StatePublished - 2000
Externally publishedYes

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