Abstract
Stimulation of postganglionic cardiac sympathetic nerves produced a stimulation frequency‐dependent overflow of endogenous noradrenaline from the otherwise isolated rat heart. Such nerve stimulation also produced increases in heart rate. There was significant correlation between heart rate increases and corresponding noradrenaline concentrations in the coronary venous effluent. Cocaine (3 × 10−5 M) caused a significant reduction in both the noradrenaline overflow and the heart rate increase, produced by nerve stimulation for 1 min at 4 Hz. Desipramine (10−6M) caused a significant increase in the noradrenaline overflow produced by stimulation for 1 min (4 Hz) with a mean increase of approximately 60%. There was no significant effect on the heart rate increase produced by such stimulation. The opposite effects of cocaine (3 × 10−5M) and desipramine (10−6M) on noradrenaline overflow are attributed to differences in the local anaesthetic properties of these agents. 1983 British Pharmacological Society
| Original language | English |
|---|---|
| Pages (from-to) | 71-74 |
| Number of pages | 4 |
| Journal | British Journal of Pharmacology |
| Volume | 79 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 1983 |
| Externally published | Yes |