Effect of thyrotropin-releasing hormone (TRH) on the chemiluminescence (CL) activity of human mononuclear cells

C. Lersch, C. Hammer, F. Krombach, H. Dancygier

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The effect of the tripeptide TRH on the chemiluminescence activity of human monocytes was tested. TRH significantly (p < 0.002) inhibited monocytes activity at pharmacological concentrations of 2 x 10-4 M/L. The effect was not mediated via Ia or C3a-receptors as was proven by the preincubation of monocytes with the monoclonal antibodies OKIa1 and anti-C3a. Heat inactivation abolished the effect of TRH. This study has demonstrated for the first time, that pharmacological doses of TRH which had already been tentatively employed as a therapeutic agent in men can modulate immunocompetent cells.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalJournal of Clinical and Laboratory Immunology
Volume28
Issue number2
StatePublished - 1989

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