Abstract
The effect of the tripeptide TRH on the chemiluminescence activity of human monocytes was tested. TRH significantly (p < 0.002) inhibited monocytes activity at pharmacological concentrations of 2 x 10-4 M/L. The effect was not mediated via Ia or C3a-receptors as was proven by the preincubation of monocytes with the monoclonal antibodies OKIa1 and anti-C3a. Heat inactivation abolished the effect of TRH. This study has demonstrated for the first time, that pharmacological doses of TRH which had already been tentatively employed as a therapeutic agent in men can modulate immunocompetent cells.
Original language | English |
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Pages (from-to) | 69-71 |
Number of pages | 3 |
Journal | Journal of Clinical and Laboratory Immunology |
Volume | 28 |
Issue number | 2 |
State | Published - 1989 |