TY - JOUR
T1 - Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced toxicity
AU - Rozman, Karl
AU - Rozman, Tibor
AU - Greim, Hemut
PY - 1984/2
Y1 - 1984/2
N2 - Chemical thyroidectomy effectively protected athyroid rats from mortality during 45 days after dosing with 100 μg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg, whereas 70 to 80% of nonthyroidectomized-euthyroid and thyroidectomized-T4 (thyroxine)-maintained-euthyroid rats died within the same period of time. There was a significant decrease in body weight of all TCDD-treated groups compared to vehicle controls. However, body weight loss was much slower in thyroidectomized-athyroid (≅1 g/day) than in nonthyroidectomized-euthyroid or in thyroidectomized-T4-euthyroid (≅8 g/day) rats. TCDD significantly reduced feed intake in nonthyroidectomized-euthyroid and thyroidectomized-T4-euthyroid rats, but no altered feed consumption was observable in thyroidectomized-athyroid animals. These data indicate that thyroid hormone(s) play(s) an important role in mediating the toxicity of TCDD.
AB - Chemical thyroidectomy effectively protected athyroid rats from mortality during 45 days after dosing with 100 μg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg, whereas 70 to 80% of nonthyroidectomized-euthyroid and thyroidectomized-T4 (thyroxine)-maintained-euthyroid rats died within the same period of time. There was a significant decrease in body weight of all TCDD-treated groups compared to vehicle controls. However, body weight loss was much slower in thyroidectomized-athyroid (≅1 g/day) than in nonthyroidectomized-euthyroid or in thyroidectomized-T4-euthyroid (≅8 g/day) rats. TCDD significantly reduced feed intake in nonthyroidectomized-euthyroid and thyroidectomized-T4-euthyroid rats, but no altered feed consumption was observable in thyroidectomized-athyroid animals. These data indicate that thyroid hormone(s) play(s) an important role in mediating the toxicity of TCDD.
UR - http://www.scopus.com/inward/record.url?scp=0021357125&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(84)90322-3
DO - 10.1016/0041-008X(84)90322-3
M3 - Article
C2 - 6695381
AN - SCOPUS:0021357125
SN - 0041-008X
VL - 72
SP - 372
EP - 376
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 2
ER -