Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced toxicity

Karl Rozman, Tibor Rozman, Hemut Greim

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Chemical thyroidectomy effectively protected athyroid rats from mortality during 45 days after dosing with 100 μg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg, whereas 70 to 80% of nonthyroidectomized-euthyroid and thyroidectomized-T4 (thyroxine)-maintained-euthyroid rats died within the same period of time. There was a significant decrease in body weight of all TCDD-treated groups compared to vehicle controls. However, body weight loss was much slower in thyroidectomized-athyroid (≅1 g/day) than in nonthyroidectomized-euthyroid or in thyroidectomized-T4-euthyroid (≅8 g/day) rats. TCDD significantly reduced feed intake in nonthyroidectomized-euthyroid and thyroidectomized-T4-euthyroid rats, but no altered feed consumption was observable in thyroidectomized-athyroid animals. These data indicate that thyroid hormone(s) play(s) an important role in mediating the toxicity of TCDD.

Original languageEnglish
Pages (from-to)372-376
Number of pages5
JournalToxicology and Applied Pharmacology
Volume72
Issue number2
DOIs
StatePublished - Feb 1984
Externally publishedYes

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