Effect of Procedural Technique on Cardiovascular Outcomes Following Second-Generation Drug-Eluting Resorbable Magnesium Scaffold Implantation

Yuichi Ozaki, Hector M. Garcia-Garcia, Gebremedhin D. Melaku, Michael Joner, Stefano Galli, Stefan Verheye, Michael K.Y. Lee, Ron Waksman, Michael Haude

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: This study sought to assess target lesion failure (TLF) and clinically driven target lesion revascularization (CD-TLR) through 1 year following second-generation drug-eluting magnesium scaffold (Magmaris) implantation using a dedicated technique (so-called “4 P's” strategy). Methods and results: The 4 P's strategy stands for: correct patient selection, proper scaffold sizing, pre-dilatation (<20% residual stenosis), post-dilatation. All the patient and lesion characteristics, preparation, and sizing of the device were compared in patients with TLF and CD-TLR through 1-year follow-up. We analyzed 315 patients for this study. At 1 year, there were 14 TLFs and 10 CD-TLRs. The TLF rates were 7.7%, 4.9%, and 4.1%; while the CD-TLR rates were 7.7%, 2.5%, and 3.2% in the undersized, properly sized, and oversized vessel groups, correspondingly. Diameter stenosis (DS) after pre-dilatation in patients with TLF and CD-TLR was significantly greater than in those without TLF and CD-TLR. In patients with a properly sized scaffold, DS after pre-dilatation was similar in patients with and without TLF and CD-TLR. However, in patients with non-properly sized scaffolds, greater post-balloon DS was observed in patients with TLF and CD-TLR. Conclusions: Improper sizing and poor lesion preparation before Magmaris implantation appear to be related to TLF during 1-year follow-up.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCardiovascular Revascularization Medicine
Volume29
DOIs
StatePublished - Aug 2021

Keywords

  • Procedure
  • Resorbable magnesium scaffold
  • Target lesion failure

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