Effect of Pre-Hospital Ticagrelor during the First 24 h after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction the ATLANTIC-H24 Analysis

Gilles Montalescot; Arnoud W. Van 'T Hof; Leonardo Bolognese; Warren J. Cantor; Angel Cequier; Mohamed Chettibi; Jean Philippe Collet; Shaun G. Goodman; Christopher J. Hammett; Kurt Huber; Magnus Janzon; Frédéric Lapostolle; Jens Flensted Lassen; Muriel Licour; Béla Merkely; Néjoua Salhi; Johanne Silvain; Robert F. Storey; Jurriën M. Ten Berg; Anne Tsatsaris; Uwe Zeymer; Eric Vicaut; Christian W. Hamm; Rachid Bougherbal; Mohamed Tahar Bouafia; Djamaleddine Nibouche; Abdelkader Moklati; Ahmed Benalia; Omar Kaid; Messaad Krim; Paul Garrahy; Rohan Jayasinghe; Stephen Rashford; Thomas Neunteufl; Helmut Brussee; Hannes Alber; Franz Weidinger; Michael Brunner; Johann Sipoetz; Gerhard Prause; Michael Baubin; Dieter Sebald; Ram Vijayaraghavan; Iqbal Bata; Andrea Lavoie; Jan Ravkilde; Lisette Okkels Jensen; Alf Møl Christensen; Marianne Toftegaard; Dennis Köhler; Gregory Ducrocq; Nicolas Danchin; Patrick Henry; Bernard Livarek; Romain Berthier; Thomas Hovasse; Philippe Garot; Laurent Payot; Hakim Benamer; Jean Baptiste Esteve; Simon Elhadad; Emmanuel Teiger; Jean Louis Bonnet; Franck Paganelli; Yves Cottin; François Schiele; Christophe Thuaire; Guillaume Cayla; Pierre Coste; Patrick Ohlmann; Eric Bonnefoy Cudraz; Pierre Lantelme; Thibault Perret; Christophe Tron; Axel De Labriolle; Edouardo Aptecar; Olivier Beliard; Olivier Varenne; Rami El Mahmoud; Emmanuelle Filippi-Codaccioni; Denis Angoulvant; Patrick Peycher; Olivier Poitrineau; Xavier Tabone; Patrick Ecollan; Claire Broche; Yves Lambert; Nicolas Briole; Arielle Beruben; Nicolas Porcher; Jean Pierre Auffray; Marc Freysz; Franck Depardieu; David Poubel; Jean Emmanuel De La Cousaye; Jean Claude Bartier; Benoît Jardel; Bertrand Boulanger; Hervé Labourel; Louis Christophe Soulat; Véronique Julie; Michel Thicoipe; Olivier Capel; Olivier Stibbe; Pierre Carli; Karim Tazarourte; Fabrice Alcouffe; David Aboucaya; Gaële Aubert; Gérald Kierzek; Séverine Cahun-Giraud; Thomas Dengler; Roland Prondzinsky; Paul Marc Biever; Andreas Schäfer; Melchior Seyfarth; Bernd Lemke; Gerald Werner; Holger Nef; Holger Steiger; Matthias Leschke; Thomas Münzel; Marco Campo Dell Orto; Christian Loges; Monika Schinke; Frank Koberne; Hans Peter Reiffen; Klaus Tiroch; Dirk Wierich; Michael Kneussel; Simon Little; Hartmut Sauer; Rita Laufenberg-Feldmann; Imre Ungi; Iván Horváth; István Édes; István Mártai; Sergio Berti; Francesco Chiarella; Paolo Calabria; Massimo Fineschi; Marcello Galvani; Marco Valgimigli; Luciano Moretti; Maurizio Tespili; Massimo Mandó; Francesco Bermano; Robusto Biagioni; Andrea Fabbri; Adelina Ricciardelli; Maria Romana Petroni; Umberto Roberto Vatteroni; Francesco Palumbo; Frank F. Willems; Amar Al Mafragi; Ton A.A.C.M. Heestermans; Martijn J. Van Eck; Wim M.J.M. Heutz; H. H. Meppelder; Anika Roukema De Jong; Harm Van De Pas; Ángel Cequier Fillat; Manel Sabaté Tenas; Josepa Mauri Ferrer; Antoni Serra Peñaranda; Joan Ángel Ferrer; Bruno García Del Blanco; Faustino Miranda Guardiola; Juan Miguel Ruiz Nodar; Andrés Íñiguez Romo; Nicolás Vázquez González; Ramiro Trillo Nouche; Luis Díaz De La Llera; José María Hernández García; Fernando Rivero-Crespo; Felipe Hernández Hernández; José Luis Zamorano Gómez; Xavier Jiménez Fárega; Gilberto Alonso Fernández; José Luis Toboso; Mercedes Carrasco; Victoria Barreiro; José Antonio Iglesias Vázquez; María Del Mar Ruiz Montero; Fernando Rosell Ortiz; Guillermo Garcia Escudero; Vicente Sánchez Brunete Ingelmo; Antonio Lara García; Jonas Oldgren; Fredrik Calais; Robert Kastberg; Per Adolf Bergsten; Hans Blomberg; Kristian Thörn; Gunnar Skoog; Azfar Zaman; Robert Gerber; Alisdair Ryding; Mark Spence; Neil Swanson; Martin Been; Konrad Grosser; Peter Schofield; David Mackin; Paul Fell; Tom Quinn; Teresa Foster; David McManus; Andy Carson

doi:10.1016/j.jcin.2015.12.024

Effect of Pre-Hospital Ticagrelor during the First 24 h after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction the ATLANTIC-H²⁴ Analysis

Gilles Montalescot, Arnoud W. Van 'T Hof, Leonardo Bolognese, Warren J. Cantor, Angel Cequier, Mohamed Chettibi, Jean Philippe Collet, Shaun G. Goodman, Christopher J. Hammett, Kurt Huber, Magnus Janzon, Frédéric Lapostolle, Jens Flensted Lassen, Muriel Licour, Béla Merkely, Néjoua Salhi, Johanne Silvain, Robert F. Storey, Jurriën M. Ten Berg, Anne TsatsarisUwe Zeymer, Eric Vicaut, Christian W. Hamm, Rachid Bougherbal, Mohamed Tahar Bouafia, Djamaleddine Nibouche, Abdelkader Moklati, Ahmed Benalia, Omar Kaid, Messaad Krim, Paul Garrahy, Rohan Jayasinghe, Stephen Rashford, Thomas Neunteufl, Helmut Brussee, Hannes Alber, Franz Weidinger, Michael Brunner, Johann Sipoetz, Gerhard Prause, Michael Baubin, Dieter Sebald, Ram Vijayaraghavan, Iqbal Bata, Andrea Lavoie, Jan Ravkilde, Lisette Okkels Jensen, Alf Møl Christensen, Marianne Toftegaard, Dennis Köhler, Gregory Ducrocq, Nicolas Danchin, Patrick Henry, Bernard Livarek, Romain Berthier, Thomas Hovasse, Philippe Garot, Laurent Payot, Hakim Benamer, Jean Baptiste Esteve, Simon Elhadad, Emmanuel Teiger, Jean Louis Bonnet, Franck Paganelli, Yves Cottin, François Schiele, Christophe Thuaire, Guillaume Cayla, Pierre Coste, Patrick Ohlmann, Eric Bonnefoy Cudraz, Pierre Lantelme, Thibault Perret, Christophe Tron, Axel De Labriolle, Edouardo Aptecar, Olivier Beliard, Olivier Varenne, Rami El Mahmoud, Emmanuelle Filippi-Codaccioni, Denis Angoulvant, Patrick Peycher, Olivier Poitrineau, Xavier Tabone, Patrick Ecollan, Claire Broche, Yves Lambert, Nicolas Briole, Arielle Beruben, Nicolas Porcher, Jean Pierre Auffray, Marc Freysz, Franck Depardieu, David Poubel, Jean Emmanuel De La Cousaye, Jean Claude Bartier, Benoît Jardel, Bertrand Boulanger, Hervé Labourel, Louis Christophe Soulat, Véronique Julie, Michel Thicoipe, Olivier Capel, Olivier Stibbe, Pierre Carli, Karim Tazarourte, Fabrice Alcouffe, David Aboucaya, Gaële Aubert, Gérald Kierzek, Séverine Cahun-Giraud, Thomas Dengler, Roland Prondzinsky, Paul Marc Biever, Andreas Schäfer, Melchior Seyfarth, Bernd Lemke, Gerald Werner, Holger Nef, Holger Steiger, Matthias Leschke, Thomas Münzel, Marco Campo Dell Orto, Christian Loges, Monika Schinke, Frank Koberne, Hans Peter Reiffen, Klaus Tiroch, Dirk Wierich, Michael Kneussel, Simon Little, Hartmut Sauer, Rita Laufenberg-Feldmann, Imre Ungi, Iván Horváth, István Édes, István Mártai, Sergio Berti, Francesco Chiarella, Paolo Calabria, Massimo Fineschi, Marcello Galvani, Marco Valgimigli, Luciano Moretti, Maurizio Tespili, Massimo Mandó, Francesco Bermano, Robusto Biagioni, Andrea Fabbri, Adelina Ricciardelli, Maria Romana Petroni, Umberto Roberto Vatteroni, Francesco Palumbo, Frank F. Willems, Amar Al Mafragi, Ton A.A.C.M. Heestermans, Martijn J. Van Eck, Wim M.J.M. Heutz, H. H. Meppelder, Anika Roukema De Jong, Harm Van De Pas, Ángel Cequier Fillat, Manel Sabaté Tenas, Josepa Mauri Ferrer, Antoni Serra Peñaranda, Joan Ángel Ferrer, Bruno García Del Blanco, Faustino Miranda Guardiola, Juan Miguel Ruiz Nodar, Andrés Íñiguez Romo, Nicolás Vázquez González, Ramiro Trillo Nouche, Luis Díaz De La Llera, José María Hernández García, Fernando Rivero-Crespo, Felipe Hernández Hernández, José Luis Zamorano Gómez, Xavier Jiménez Fárega, Gilberto Alonso Fernández, José Luis Toboso, Mercedes Carrasco, Victoria Barreiro, José Antonio Iglesias Vázquez, María Del Mar Ruiz Montero, Fernando Rosell Ortiz, Guillermo Garcia Escudero, Vicente Sánchez Brunete Ingelmo, Antonio Lara García, Jonas Oldgren, Fredrik Calais, Robert Kastberg, Per Adolf Bergsten, Hans Blomberg, Kristian Thörn, Gunnar Skoog, Azfar Zaman, Robert Gerber, Alisdair Ryding, Mark Spence, Neil Swanson, Martin Been, Konrad Grosser, Peter Schofield, David Mackin, Paul Fell, Tom Quinn, Teresa Foster, David McManus, Andy Carson

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Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Objectives The aim of this landmark exploratory analysis, ATLANTIC-H²⁴, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study. Background The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min). Methods The ATLANTIC-H²⁴ analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction flow grade 3, ≥70% ST-segment elevation resolution, and clinical endpoints over the first 24 h. Results Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%; p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%; p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%; p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events. Conclusions The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality.

Original language	English
Pages (from-to)	646-656
Number of pages	11
Journal	JACC: Cardiovascular Interventions
Volume	9
Issue number	7
DOIs	https://doi.org/10.1016/j.jcin.2015.12.024
State	Published - 11 Apr 2016

Keywords

myocardial infarction
platelets
reperfusion
stents
thrombosis

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10.1016/j.jcin.2015.12.024

Cite this

Montalescot, G., Van 'T Hof, A. W., Bolognese, L., Cantor, W. J., Cequier, A., Chettibi, M., Collet, J. P., Goodman, S. G., Hammett, C. J., Huber, K., Janzon, M., Lapostolle, F., Lassen, J. F., Licour, M., Merkely, B., Salhi, N., Silvain, J., Storey, R. F., Ten Berg, J. M., ... Carson, A. (2016). Effect of Pre-Hospital Ticagrelor during the First 24 h after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction the ATLANTIC-H²⁴ Analysis. JACC: Cardiovascular Interventions, 9(7), 646-656. https://doi.org/10.1016/j.jcin.2015.12.024

@article{5df0f49339444282a6ea5195de62e6fd,

title = "Effect of Pre-Hospital Ticagrelor during the First 24 h after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction the ATLANTIC-H24 Analysis",

abstract = "Objectives The aim of this landmark exploratory analysis, ATLANTIC-H24, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study. Background The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min). Methods The ATLANTIC-H24 analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction flow grade 3, ≥70% ST-segment elevation resolution, and clinical endpoints over the first 24 h. Results Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%; p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%; p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%; p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events. Conclusions The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality.",

keywords = "myocardial infarction, platelets, reperfusion, stents, thrombosis",

author = "Gilles Montalescot and {Van 'T Hof}, {Arnoud W.} and Leonardo Bolognese and Cantor, {Warren J.} and Angel Cequier and Mohamed Chettibi and Collet, {Jean Philippe} and Goodman, {Shaun G.} and Hammett, {Christopher J.} and Kurt Huber and Magnus Janzon and Fr{\'e}d{\'e}ric Lapostolle and Lassen, {Jens Flensted} and Muriel Licour and B{\'e}la Merkely and N{\'e}joua Salhi and Johanne Silvain and Storey, {Robert F.} and {Ten Berg}, {Jurri{\"e}n M.} and Anne Tsatsaris and Uwe Zeymer and Eric Vicaut and Hamm, {Christian W.} and Rachid Bougherbal and Bouafia, {Mohamed Tahar} and Djamaleddine Nibouche and Abdelkader Moklati and Ahmed Benalia and Omar Kaid and Messaad Krim and Paul Garrahy and Rohan Jayasinghe and Stephen Rashford and Thomas Neunteufl and Helmut Brussee and Hannes Alber and Franz Weidinger and Michael Brunner and Johann Sipoetz and Gerhard Prause and Michael Baubin and Dieter Sebald and Ram Vijayaraghavan and Iqbal Bata and Andrea Lavoie and Jan Ravkilde and Jensen, {Lisette Okkels} and Christensen, {Alf M{\o}l} and Marianne Toftegaard and Dennis K{\"o}hler and Gregory Ducrocq and Nicolas Danchin and Patrick Henry and Bernard Livarek and Romain Berthier and Thomas Hovasse and Philippe Garot and Laurent Payot and Hakim Benamer and Esteve, {Jean Baptiste} and Simon Elhadad and Emmanuel Teiger and Bonnet, {Jean Louis} and Franck Paganelli and Yves Cottin and Fran{\c c}ois Schiele and Christophe Thuaire and Guillaume Cayla and Pierre Coste and Patrick Ohlmann and Cudraz, {Eric Bonnefoy} and Pierre Lantelme and Thibault Perret and Christophe Tron and {De Labriolle}, Axel and Edouardo Aptecar and Olivier Beliard and Olivier Varenne and {El Mahmoud}, Rami and Emmanuelle Filippi-Codaccioni and Denis Angoulvant and Patrick Peycher and Olivier Poitrineau and Xavier Tabone and Patrick Ecollan and Claire Broche and Yves Lambert and Nicolas Briole and Arielle Beruben and Nicolas Porcher and Auffray, {Jean Pierre} and Marc Freysz and Franck Depardieu and David Poubel and {De La Cousaye}, {Jean Emmanuel} and Bartier, {Jean Claude} and Beno{\^i}t Jardel and Bertrand Boulanger and Herv{\'e} Labourel and Soulat, {Louis Christophe} and V{\'e}ronique Julie and Michel Thicoipe and Olivier Capel and Olivier Stibbe and Pierre Carli and Karim Tazarourte and Fabrice Alcouffe and David Aboucaya and Ga{\"e}le Aubert and G{\'e}rald Kierzek and S{\'e}verine Cahun-Giraud and Thomas Dengler and Roland Prondzinsky and Biever, {Paul Marc} and Andreas Sch{\"a}fer and Melchior Seyfarth and Bernd Lemke and Gerald Werner and Holger Nef and Holger Steiger and Matthias Leschke and Thomas M{\"u}nzel and {Dell Orto}, {Marco Campo} and Christian Loges and Monika Schinke and Frank Koberne and Reiffen, {Hans Peter} and Klaus Tiroch and Dirk Wierich and Michael Kneussel and Simon Little and Hartmut Sauer and Rita Laufenberg-Feldmann and Imre Ungi and Iv{\'a}n Horv{\'a}th and Istv{\'a}n {\'E}des and Istv{\'a}n M{\'a}rtai and Sergio Berti and Francesco Chiarella and Paolo Calabria and Massimo Fineschi and Marcello Galvani and Marco Valgimigli and Luciano Moretti and Maurizio Tespili and Massimo Mand{\'o} and Francesco Bermano and Robusto Biagioni and Andrea Fabbri and Adelina Ricciardelli and Petroni, {Maria Romana} and Vatteroni, {Umberto Roberto} and Francesco Palumbo and Willems, {Frank F.} and {Al Mafragi}, Amar and Heestermans, {Ton A.A.C.M.} and {Van Eck}, {Martijn J.} and Heutz, {Wim M.J.M.} and Meppelder, {H. H.} and Jong, {Anika Roukema De} and {Van De Pas}, Harm and Fillat, {{\'A}ngel Cequier} and Tenas, {Manel Sabat{\'e}} and Ferrer, {Josepa Mauri} and Pe{\~n}aranda, {Antoni Serra} and Ferrer, {Joan {\'A}ngel} and {Del Blanco}, {Bruno Garc{\'i}a} and Guardiola, {Faustino Miranda} and {Ruiz Nodar}, {Juan Miguel} and Romo, {Andr{\'e}s {\'I}{\~n}iguez} and Gonz{\'a}lez, {Nicol{\'a}s V{\'a}zquez} and Nouche, {Ramiro Trillo} and {De La Llera}, {Luis D{\'i}az} and {Hern{\'a}ndez Garc{\'i}a}, {Jos{\'e} Mar{\'i}a} and Fernando Rivero-Crespo and Hern{\'a}ndez, {Felipe Hern{\'a}ndez} and {Zamorano G{\'o}mez}, {Jos{\'e} Luis} and F{\'a}rega, {Xavier Jim{\'e}nez} and Fern{\'a}ndez, {Gilberto Alonso} and Toboso, {Jos{\'e} Luis} and Mercedes Carrasco and Victoria Barreiro and {Iglesias V{\'a}zquez}, {Jos{\'e} Antonio} and Montero, {Mar{\'i}a Del Mar Ruiz} and Ortiz, {Fernando Rosell} and Escudero, {Guillermo Garcia} and Ingelmo, {Vicente S{\'a}nchez Brunete} and Garc{\'i}a, {Antonio Lara} and Jonas Oldgren and Fredrik Calais and Robert Kastberg and Bergsten, {Per Adolf} and Hans Blomberg and Kristian Th{\"o}rn and Gunnar Skoog and Azfar Zaman and Robert Gerber and Alisdair Ryding and Mark Spence and Neil Swanson and Martin Been and Konrad Grosser and Peter Schofield and David Mackin and Paul Fell and Tom Quinn and Teresa Foster and David McManus and Andy Carson",

note = "Publisher Copyright: {\textcopyright} 2016 American College of Cardiology Foundation.",

year = "2016",

month = apr,

day = "11",

doi = "10.1016/j.jcin.2015.12.024",

language = "English",

volume = "9",

pages = "646--656",

journal = "JACC: Cardiovascular Interventions",

issn = "1936-8798",

publisher = "Elsevier Inc.",

number = "7",

}

Montalescot, G, Van 'T Hof, AW, Bolognese, L, Cantor, WJ, Cequier, A, Chettibi, M, Collet, JP, Goodman, SG, Hammett, CJ, Huber, K, Janzon, M, Lapostolle, F, Lassen, JF, Licour, M, Merkely, B, Salhi, N, Silvain, J, Storey, RF, Ten Berg, JM, Tsatsaris, A, Zeymer, U, Vicaut, E, Hamm, CW, Bougherbal, R, Bouafia, MT, Nibouche, D, Moklati, A, Benalia, A, Kaid, O, Krim, M, Garrahy, P, Jayasinghe, R, Rashford, S, Neunteufl, T, Brussee, H, Alber, H, Weidinger, F, Brunner, M, Sipoetz, J, Prause, G, Baubin, M, Sebald, D, Vijayaraghavan, R, Bata, I, Lavoie, A, Ravkilde, J, Jensen, LO, Christensen, AM, Toftegaard, M, Köhler, D, Ducrocq, G, Danchin, N, Henry, P, Livarek, B, Berthier, R, Hovasse, T, Garot, P, Payot, L, Benamer, H, Esteve, JB, Elhadad, S, Teiger, E, Bonnet, JL, Paganelli, F, Cottin, Y, Schiele, F, Thuaire, C, Cayla, G, Coste, P, Ohlmann, P, Cudraz, EB, Lantelme, P, Perret, T, Tron, C, De Labriolle, A, Aptecar, E, Beliard, O, Varenne, O, El Mahmoud, R, Filippi-Codaccioni, E, Angoulvant, D, Peycher, P, Poitrineau, O, Tabone, X, Ecollan, P, Broche, C, Lambert, Y, Briole, N, Beruben, A, Porcher, N, Auffray, JP, Freysz, M, Depardieu, F, Poubel, D, De La Cousaye, JE, Bartier, JC, Jardel, B, Boulanger, B, Labourel, H, Soulat, LC, Julie, V, Thicoipe, M, Capel, O, Stibbe, O, Carli, P, Tazarourte, K, Alcouffe, F, Aboucaya, D, Aubert, G, Kierzek, G, Cahun-Giraud, S, Dengler, T, Prondzinsky, R, Biever, PM, Schäfer, A, Seyfarth, M, Lemke, B, Werner, G, Nef, H, Steiger, H, Leschke, M, Münzel, T, Dell Orto, MC, Loges, C, Schinke, M, Koberne, F, Reiffen, HP, Tiroch, K, Wierich, D, Kneussel, M, Little, S, Sauer, H, Laufenberg-Feldmann, R, Ungi, I, Horváth, I, Édes, I, Mártai, I, Berti, S, Chiarella, F, Calabria, P, Fineschi, M, Galvani, M, Valgimigli, M, Moretti, L, Tespili, M, Mandó, M, Bermano, F, Biagioni, R, Fabbri, A, Ricciardelli, A, Petroni, MR, Vatteroni, UR, Palumbo, F, Willems, FF, Al Mafragi, A, Heestermans, TAACM, Van Eck, MJ, Heutz, WMJM, Meppelder, HH, Jong, ARD, Van De Pas, H, Fillat, ÁC, Tenas, MS, Ferrer, JM, Peñaranda, AS, Ferrer, JÁ, Del Blanco, BG, Guardiola, FM, Ruiz Nodar, JM, Romo, AÍ, González, NV, Nouche, RT, De La Llera, LD, Hernández García, JM, Rivero-Crespo, F, Hernández, FH, Zamorano Gómez, JL, Fárega, XJ, Fernández, GA, Toboso, JL, Carrasco, M, Barreiro, V, Iglesias Vázquez, JA, Montero, MDMR, Ortiz, FR, Escudero, GG, Ingelmo, VSB, García, AL, Oldgren, J, Calais, F, Kastberg, R, Bergsten, PA, Blomberg, H, Thörn, K, Skoog, G, Zaman, A, Gerber, R, Ryding, A, Spence, M, Swanson, N, Been, M, Grosser, K, Schofield, P, Mackin, D, Fell, P, Quinn, T, Foster, T, McManus, D & Carson, A 2016, 'Effect of Pre-Hospital Ticagrelor during the First 24 h after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction the ATLANTIC-H²⁴ Analysis', JACC: Cardiovascular Interventions, vol. 9, no. 7, pp. 646-656. https://doi.org/10.1016/j.jcin.2015.12.024

Effect of Pre-Hospital Ticagrelor during the First 24 h after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction the ATLANTIC-H²⁴ Analysis. / Montalescot, Gilles; Van 'T Hof, Arnoud W.; Bolognese, Leonardo et al.
In: JACC: Cardiovascular Interventions, Vol. 9, No. 7, 11.04.2016, p. 646-656.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of Pre-Hospital Ticagrelor during the First 24 h after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction the ATLANTIC-H24 Analysis

AU - Montalescot, Gilles

AU - Van 'T Hof, Arnoud W.

AU - Bolognese, Leonardo

AU - Cantor, Warren J.

AU - Cequier, Angel

AU - Chettibi, Mohamed

AU - Collet, Jean Philippe

AU - Goodman, Shaun G.

AU - Hammett, Christopher J.

AU - Huber, Kurt

AU - Janzon, Magnus

AU - Lapostolle, Frédéric

AU - Lassen, Jens Flensted

AU - Licour, Muriel

AU - Merkely, Béla

AU - Salhi, Néjoua

AU - Silvain, Johanne

AU - Storey, Robert F.

AU - Ten Berg, Jurriën M.

AU - Tsatsaris, Anne

AU - Zeymer, Uwe

AU - Vicaut, Eric

AU - Hamm, Christian W.

AU - Bougherbal, Rachid

AU - Bouafia, Mohamed Tahar

AU - Nibouche, Djamaleddine

AU - Moklati, Abdelkader

AU - Benalia, Ahmed

AU - Kaid, Omar

AU - Krim, Messaad

AU - Garrahy, Paul

AU - Jayasinghe, Rohan

AU - Rashford, Stephen

AU - Neunteufl, Thomas

AU - Brussee, Helmut

AU - Alber, Hannes

AU - Weidinger, Franz

AU - Brunner, Michael

AU - Sipoetz, Johann

AU - Prause, Gerhard

AU - Baubin, Michael

AU - Sebald, Dieter

AU - Vijayaraghavan, Ram

AU - Bata, Iqbal

AU - Lavoie, Andrea

AU - Ravkilde, Jan

AU - Jensen, Lisette Okkels

AU - Christensen, Alf Møl

AU - Toftegaard, Marianne

AU - Köhler, Dennis

AU - Ducrocq, Gregory

AU - Danchin, Nicolas

AU - Henry, Patrick

AU - Livarek, Bernard

AU - Berthier, Romain

AU - Hovasse, Thomas

AU - Garot, Philippe

AU - Payot, Laurent

AU - Benamer, Hakim

AU - Esteve, Jean Baptiste

AU - Elhadad, Simon

AU - Teiger, Emmanuel

AU - Bonnet, Jean Louis

AU - Paganelli, Franck

AU - Cottin, Yves

AU - Schiele, François

AU - Thuaire, Christophe

AU - Cayla, Guillaume

AU - Coste, Pierre

AU - Ohlmann, Patrick

AU - Cudraz, Eric Bonnefoy

AU - Lantelme, Pierre

AU - Perret, Thibault

AU - Tron, Christophe

AU - De Labriolle, Axel

AU - Aptecar, Edouardo

AU - Beliard, Olivier

AU - Varenne, Olivier

AU - El Mahmoud, Rami

AU - Filippi-Codaccioni, Emmanuelle

AU - Angoulvant, Denis

AU - Peycher, Patrick

AU - Poitrineau, Olivier

AU - Tabone, Xavier

AU - Ecollan, Patrick

AU - Broche, Claire

AU - Lambert, Yves

AU - Briole, Nicolas

AU - Beruben, Arielle

AU - Porcher, Nicolas

AU - Auffray, Jean Pierre

AU - Freysz, Marc

AU - Depardieu, Franck

AU - Poubel, David

AU - De La Cousaye, Jean Emmanuel

AU - Bartier, Jean Claude

AU - Jardel, Benoît

AU - Boulanger, Bertrand

AU - Labourel, Hervé

AU - Soulat, Louis Christophe

AU - Julie, Véronique

AU - Thicoipe, Michel

AU - Capel, Olivier

AU - Stibbe, Olivier

AU - Carli, Pierre

AU - Tazarourte, Karim

AU - Alcouffe, Fabrice

AU - Aboucaya, David

AU - Aubert, Gaële

AU - Kierzek, Gérald

AU - Cahun-Giraud, Séverine

AU - Dengler, Thomas

AU - Prondzinsky, Roland

AU - Biever, Paul Marc

AU - Schäfer, Andreas

AU - Seyfarth, Melchior

AU - Lemke, Bernd

AU - Werner, Gerald

AU - Nef, Holger

AU - Steiger, Holger

AU - Leschke, Matthias

AU - Münzel, Thomas

AU - Dell Orto, Marco Campo

AU - Loges, Christian

AU - Schinke, Monika

AU - Koberne, Frank

AU - Reiffen, Hans Peter

AU - Tiroch, Klaus

AU - Wierich, Dirk

AU - Kneussel, Michael

AU - Little, Simon

AU - Sauer, Hartmut

AU - Laufenberg-Feldmann, Rita

AU - Ungi, Imre

AU - Horváth, Iván

AU - Édes, István

AU - Mártai, István

AU - Berti, Sergio

AU - Chiarella, Francesco

AU - Calabria, Paolo

AU - Fineschi, Massimo

AU - Galvani, Marcello

AU - Valgimigli, Marco

AU - Moretti, Luciano

AU - Tespili, Maurizio

AU - Mandó, Massimo

AU - Bermano, Francesco

AU - Biagioni, Robusto

AU - Fabbri, Andrea

AU - Ricciardelli, Adelina

AU - Petroni, Maria Romana

AU - Vatteroni, Umberto Roberto

AU - Palumbo, Francesco

AU - Willems, Frank F.

AU - Al Mafragi, Amar

AU - Heestermans, Ton A.A.C.M.

AU - Van Eck, Martijn J.

AU - Heutz, Wim M.J.M.

AU - Meppelder, H. H.

AU - Jong, Anika Roukema De

AU - Van De Pas, Harm

AU - Fillat, Ángel Cequier

AU - Tenas, Manel Sabaté

AU - Ferrer, Josepa Mauri

AU - Peñaranda, Antoni Serra

AU - Ferrer, Joan Ángel

AU - Del Blanco, Bruno García

AU - Guardiola, Faustino Miranda

AU - Ruiz Nodar, Juan Miguel

AU - Romo, Andrés Íñiguez

AU - González, Nicolás Vázquez

AU - Nouche, Ramiro Trillo

AU - De La Llera, Luis Díaz

AU - Hernández García, José María

AU - Rivero-Crespo, Fernando

AU - Hernández, Felipe Hernández

AU - Zamorano Gómez, José Luis

AU - Fárega, Xavier Jiménez

AU - Fernández, Gilberto Alonso

AU - Toboso, José Luis

AU - Carrasco, Mercedes

AU - Barreiro, Victoria

AU - Iglesias Vázquez, José Antonio

AU - Montero, María Del Mar Ruiz

AU - Ortiz, Fernando Rosell

AU - Escudero, Guillermo Garcia

AU - Ingelmo, Vicente Sánchez Brunete

AU - García, Antonio Lara

AU - Oldgren, Jonas

AU - Calais, Fredrik

AU - Kastberg, Robert

AU - Bergsten, Per Adolf

AU - Blomberg, Hans

AU - Thörn, Kristian

AU - Skoog, Gunnar

AU - Zaman, Azfar

AU - Gerber, Robert

AU - Ryding, Alisdair

AU - Spence, Mark

AU - Swanson, Neil

AU - Been, Martin

AU - Grosser, Konrad

AU - Schofield, Peter

AU - Mackin, David

AU - Fell, Paul

AU - Quinn, Tom

AU - Foster, Teresa

AU - McManus, David

AU - Carson, Andy

PY - 2016/4/11

Y1 - 2016/4/11

N2 - Objectives The aim of this landmark exploratory analysis, ATLANTIC-H24, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study. Background The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min). Methods The ATLANTIC-H24 analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction flow grade 3, ≥70% ST-segment elevation resolution, and clinical endpoints over the first 24 h. Results Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%; p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%; p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%; p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events. Conclusions The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality.

AB - Objectives The aim of this landmark exploratory analysis, ATLANTIC-H24, was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study. Background The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min). Methods The ATLANTIC-H24 analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction flow grade 3, ≥70% ST-segment elevation resolution, and clinical endpoints over the first 24 h. Results Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%; p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%; p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%; p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events. Conclusions The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality.

KW - myocardial infarction

KW - platelets

KW - reperfusion

KW - stents

KW - thrombosis

UR - http://www.scopus.com/inward/record.url?scp=84959464492&partnerID=8YFLogxK

U2 - 10.1016/j.jcin.2015.12.024

DO - 10.1016/j.jcin.2015.12.024

M3 - Article

C2 - 26952907

AN - SCOPUS:84959464492

SN - 1936-8798

VL - 9

SP - 646

EP - 656

JO - JACC: Cardiovascular Interventions

JF - JACC: Cardiovascular Interventions

IS - 7

ER -

Effect of Pre-Hospital Ticagrelor during the First 24 h after Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction the ATLANTIC-H²⁴ Analysis

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