Effect of met-enkephalin and met-enkephalin-ARG6-PHE7 on bombesin-like immunoreactivity (BLI), somatostatin and gastrin secretion from the perfused rat stomach

S. Madaus, V. Schusdziarra, T. Erberl, T. Seufferlein, M. Classen

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Abstract

In the present study we examined the effect of the two endogenous opioids met-enkephalin and met-enkephalin Arg6 Phe7 on gastric bombesin-like immunoreactivity, gastrin and somatostatin release. At doses of 10-11, 10-9, 10-8 and 10-6 M both peptides elicited a significant stimulation of bombesin-like immunoreactivity secretion, while the same doses of morphine were ineffective. The stimulatory effect was abolished by naloxone. Met-enkephalin and met-enkephalin Arg6 Phe7 stimulated somatostatin secretion at a dose of 10-8 M, and this effect was reversible by naloxone. Neither peptide had any effect on gastrin secretion. In conclusion, the data demonstrate that both enkephalins must be considered potential regulators of bombesin-like immunoreactivity secretion in the rat stomach.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalHepato-Gastroenterology
Volume37
Issue number2
StatePublished - 1990

Keywords

  • endogenous opioids
  • intrinsic nervous system
  • morphine
  • naloxone
  • rat
  • stomach

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