Abstract
In the present study we examined the effect of the two endogenous opioids met-enkephalin and met-enkephalin Arg6 Phe7 on gastric bombesin-like immunoreactivity, gastrin and somatostatin release. At doses of 10-11, 10-9, 10-8 and 10-6 M both peptides elicited a significant stimulation of bombesin-like immunoreactivity secretion, while the same doses of morphine were ineffective. The stimulatory effect was abolished by naloxone. Met-enkephalin and met-enkephalin Arg6 Phe7 stimulated somatostatin secretion at a dose of 10-8 M, and this effect was reversible by naloxone. Neither peptide had any effect on gastrin secretion. In conclusion, the data demonstrate that both enkephalins must be considered potential regulators of bombesin-like immunoreactivity secretion in the rat stomach.
Original language | English |
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Pages (from-to) | 201-203 |
Number of pages | 3 |
Journal | Hepato-Gastroenterology |
Volume | 37 |
Issue number | 2 |
State | Published - 1990 |
Keywords
- endogenous opioids
- intrinsic nervous system
- morphine
- naloxone
- rat
- stomach