Effect of iron status on the absorption, speciation and tissue distribution of aluminium in rats

C. Winklhofer; C. Steinhausen; E. Beck; M. Alvarez-Brückmann; S. Kinzel; T. H. Ittel; E. Nolte

doi:10.1016/S0168-583X(00)00228-7

Effect of iron status on the absorption, speciation and tissue distribution of aluminium in rats

C. Winklhofer
, C. Steinhausen
, E. Beck
, M. Alvarez-Brückmann
, S. Kinzel
, T. H. Ittel
, E. Nolte

Chair of Experimental Astroparticle Physics

Technical University of Munich
RWTH Aachen University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Aluminium absorption, distribution and speciation in rats have been investigated by administering a single oral dose of ²⁶Al to three groups of 10 Sprague-Dawley rats with the first group having normal, the second group having iron overloaded and the third group having iron deficient status before administration. The dose was 20 ng ²⁶Al together with 200 μg ²⁷Al as AlCl₃. The rats were sacrificed 24 h after administration of ²⁶Al. Samples of blood plasma, urine, femur, liver and spleen were taken. ²⁶Al was measured in the samples with accelerator mass spectrometry. The group with iron deficiency had a larger intestinal uptake and higher concentrations in liver, spleen and plasma than the control group whereas iron overload decreased intestinal absorption and tissue concentrations of ²⁶Al.

Original language	English
Pages (from-to)	920-924
Number of pages	5
Journal	Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume	172
Issue number	1-4
DOIs	https://doi.org/10.1016/S0168-583X(00)00228-7
State	Published - 2000

Keywords

Accelerator mass spectrometry
Al
Aluminium absorption
Aluminium excretion
Aluminium speciation

Access to Document

10.1016/S0168-583X(00)00228-7

Cite this

Winklhofer, C., Steinhausen, C., Beck, E., Alvarez-Brückmann, M., Kinzel, S., Ittel, T. H., & Nolte, E. (2000). Effect of iron status on the absorption, speciation and tissue distribution of aluminium in rats. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 172(1-4), 920-924. https://doi.org/10.1016/S0168-583X(00)00228-7

@article{d990475b318942f9951b687ac63bb8be,

title = "Effect of iron status on the absorption, speciation and tissue distribution of aluminium in rats",

abstract = "Aluminium absorption, distribution and speciation in rats have been investigated by administering a single oral dose of 26Al to three groups of 10 Sprague-Dawley rats with the first group having normal, the second group having iron overloaded and the third group having iron deficient status before administration. The dose was 20 ng 26Al together with 200 μg 27Al as AlCl3. The rats were sacrificed 24 h after administration of 26Al. Samples of blood plasma, urine, femur, liver and spleen were taken. 26Al was measured in the samples with accelerator mass spectrometry. The group with iron deficiency had a larger intestinal uptake and higher concentrations in liver, spleen and plasma than the control group whereas iron overload decreased intestinal absorption and tissue concentrations of 26Al.",

keywords = "Accelerator mass spectrometry, Al, Aluminium absorption, Aluminium excretion, Aluminium speciation",

author = "C. Winklhofer and C. Steinhausen and E. Beck and M. Alvarez-Br{\"u}ckmann and S. Kinzel and Ittel, \{T. H.\} and E. Nolte",

note = "Funding Information: The work was supported by the German Research Foundation DFG. The authors would like to thank Ms Petra Vehres and Ms Marianne Schneider (RWTH Aachen) for careful preparations of the samples and Dr. E. Werner (GSF Neuherberg) for many valuable discussions.",

year = "2000",

doi = "10.1016/S0168-583X(00)00228-7",

language = "English",

volume = "172",

pages = "920--924",

journal = "Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms",

issn = "0168-583X",

publisher = "Elsevier B.V.",

number = "1-4",

}

Winklhofer, C, Steinhausen, C, Beck, E, Alvarez-Brückmann, M, Kinzel, S, Ittel, TH & Nolte, E 2000, 'Effect of iron status on the absorption, speciation and tissue distribution of aluminium in rats', Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 172, no. 1-4, pp. 920-924. https://doi.org/10.1016/S0168-583X(00)00228-7

TY - JOUR

T1 - Effect of iron status on the absorption, speciation and tissue distribution of aluminium in rats

AU - Winklhofer, C.

AU - Steinhausen, C.

AU - Beck, E.

AU - Alvarez-Brückmann, M.

AU - Kinzel, S.

AU - Ittel, T. H.

AU - Nolte, E.

N1 - Funding Information: The work was supported by the German Research Foundation DFG. The authors would like to thank Ms Petra Vehres and Ms Marianne Schneider (RWTH Aachen) for careful preparations of the samples and Dr. E. Werner (GSF Neuherberg) for many valuable discussions.

PY - 2000

Y1 - 2000

N2 - Aluminium absorption, distribution and speciation in rats have been investigated by administering a single oral dose of 26Al to three groups of 10 Sprague-Dawley rats with the first group having normal, the second group having iron overloaded and the third group having iron deficient status before administration. The dose was 20 ng 26Al together with 200 μg 27Al as AlCl3. The rats were sacrificed 24 h after administration of 26Al. Samples of blood plasma, urine, femur, liver and spleen were taken. 26Al was measured in the samples with accelerator mass spectrometry. The group with iron deficiency had a larger intestinal uptake and higher concentrations in liver, spleen and plasma than the control group whereas iron overload decreased intestinal absorption and tissue concentrations of 26Al.

AB - Aluminium absorption, distribution and speciation in rats have been investigated by administering a single oral dose of 26Al to three groups of 10 Sprague-Dawley rats with the first group having normal, the second group having iron overloaded and the third group having iron deficient status before administration. The dose was 20 ng 26Al together with 200 μg 27Al as AlCl3. The rats were sacrificed 24 h after administration of 26Al. Samples of blood plasma, urine, femur, liver and spleen were taken. 26Al was measured in the samples with accelerator mass spectrometry. The group with iron deficiency had a larger intestinal uptake and higher concentrations in liver, spleen and plasma than the control group whereas iron overload decreased intestinal absorption and tissue concentrations of 26Al.

KW - Accelerator mass spectrometry

KW - Al

KW - Aluminium absorption

KW - Aluminium excretion

KW - Aluminium speciation

UR - https://www.scopus.com/pages/publications/0034290618

U2 - 10.1016/S0168-583X(00)00228-7

DO - 10.1016/S0168-583X(00)00228-7

M3 - Article

AN - SCOPUS:0034290618

SN - 0168-583X

VL - 172

SP - 920

EP - 924

JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

IS - 1-4

ER -

Effect of iron status on the absorption, speciation and tissue distribution of aluminium in rats

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