TY - JOUR
T1 - Effect of exercise training on the fatty acid composition of lipid classes in rat liver, skeletal muscle, and adipose tissue
AU - Petridou, Anatoli
AU - Nikolaidis, Michalis G.
AU - Matsakas, Antonis
AU - Schulz, Thorsten
AU - Michna, Horst
AU - Mougios, Vassilis
PY - 2005/5
Y1 - 2005/5
N2 - The aim of the present study was to examine the effects of 8 weeks of exercise training on the fatty acid composition of phospholipids (PL) and triacylglycerols (TG) in rat liver, skeletal muscle (gastrocnemius medialis), and adipose tissue (epididymal and subcutaneous fat). For this purpose, the relevant tissues of 11 trained rats were compared to those of 14 untrained ones. Training caused several significant differences of large effect size in the concentrations and percentages of individual fatty acids in the aforementioned lipid classes. The fatty acid composition of liver PL, in terms of both concentrations and percentages, changed with training. The TG content of muscle and subcutaneous adipose tissue decreased significantly with training. In contrast to the liver, where no significant differences in the fatty acid profile of TG were found, muscle underwent more significant differences in TG than PL, and adipose tissue only in TG. Most differences were in the same direction in muscle and adipose tissue TG, suggesting a common underlying mechanism. Estimated fatty acid elongase activity was significantly higher, whereas Δ9-desaturase activity was significantly lower in muscle and adipose tissue of the trained rats. In conclusion, exercise training modified the fatty acid composition of liver PL, muscle PL and TG, as well as adipose tissue TG. These findings may aid in delineating the effects of exercise on biological functions such as membrane properties, cell signaling, and gene expression.
AB - The aim of the present study was to examine the effects of 8 weeks of exercise training on the fatty acid composition of phospholipids (PL) and triacylglycerols (TG) in rat liver, skeletal muscle (gastrocnemius medialis), and adipose tissue (epididymal and subcutaneous fat). For this purpose, the relevant tissues of 11 trained rats were compared to those of 14 untrained ones. Training caused several significant differences of large effect size in the concentrations and percentages of individual fatty acids in the aforementioned lipid classes. The fatty acid composition of liver PL, in terms of both concentrations and percentages, changed with training. The TG content of muscle and subcutaneous adipose tissue decreased significantly with training. In contrast to the liver, where no significant differences in the fatty acid profile of TG were found, muscle underwent more significant differences in TG than PL, and adipose tissue only in TG. Most differences were in the same direction in muscle and adipose tissue TG, suggesting a common underlying mechanism. Estimated fatty acid elongase activity was significantly higher, whereas Δ9-desaturase activity was significantly lower in muscle and adipose tissue of the trained rats. In conclusion, exercise training modified the fatty acid composition of liver PL, muscle PL and TG, as well as adipose tissue TG. These findings may aid in delineating the effects of exercise on biological functions such as membrane properties, cell signaling, and gene expression.
KW - 3-Hydroxyacyl CoA dehydrogenase
KW - Carnitine palmitoyltransferase
KW - Exercise
KW - Fatty acid profile
KW - Gastrocnemius
UR - http://www.scopus.com/inward/record.url?scp=23244462810&partnerID=8YFLogxK
U2 - 10.1007/s00421-004-1294-z
DO - 10.1007/s00421-004-1294-z
M3 - Article
C2 - 15682327
AN - SCOPUS:23244462810
SN - 1439-6319
VL - 94
SP - 84
EP - 92
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 1-2
ER -
