TY - JOUR
T1 - Effect of breast-feeding on the development of atopic dermatitis during the first 3 years of life - Results from the gini-birth cohort study
AU - Laubereau, Birgit
AU - Brockow, Inken
AU - Zirngibl, Angelika
AU - Koletzko, Sibylle
AU - Gruebl, Armin
AU - Von Berg, Andrea
AU - Filipiak-Pittroff, Birgit
AU - Berdel, Dietrich
AU - Bauer, Carl Peter
AU - Reinhardt, Dietrich
AU - Heinrich, Joachim
AU - Wichmann, H. Erich
N1 - Funding Information:
Supported by the Federal Ministry for Education, Science, Research and Technology, Grant No. 01 EE 9401-4 and the Child Health Foundation. Nestlé, Hipp, Milupa, Numico and Mead Johnson provided the study formulas for the intervention study.
PY - 2004/5
Y1 - 2004/5
N2 - Objective: To investigate if exclusive breast-feeding for 4 months is associated with atopic dermatitis during the first 3 years of life. Study design: Data on 3903 children were taken from yearly parental-administered questionnaires from a birth cohort study in Germany (recruited 1995-1998) comprised of a noninterventional (NI) and an interventional (I) subgroup. Outcomes were physician-diagnosed atopic dermatitis (AD) and itchy rash. Multiple logistic regression was performed for the entire cohort and stratified by family history of allergy and by study group adjusting for a fixed set of risk factors for allergies. Results: Exclusive breast-feeding (52 % of children) was not associated with higher risk for AD either in the entire cohort (OR adj, 0.95; 95% CI, 0.79-1.14) or if stratified by family history of AD. In the I subgroup, but not in the NI subgroup, exclusive breast-feeding showed a significant protective effect on AD if compared with conventional cow's milk formula (ORadj, 0.64; 95% CI, 0.45-0.90). Conclusion: These findings do not support the hypothesis that exclusive breast-feeding is a risk factor for development of atopic dermatitis but is protective if compared with conventional cow's milk. Observational studies might not be able to effectively control for selection bias and reverse causation.
AB - Objective: To investigate if exclusive breast-feeding for 4 months is associated with atopic dermatitis during the first 3 years of life. Study design: Data on 3903 children were taken from yearly parental-administered questionnaires from a birth cohort study in Germany (recruited 1995-1998) comprised of a noninterventional (NI) and an interventional (I) subgroup. Outcomes were physician-diagnosed atopic dermatitis (AD) and itchy rash. Multiple logistic regression was performed for the entire cohort and stratified by family history of allergy and by study group adjusting for a fixed set of risk factors for allergies. Results: Exclusive breast-feeding (52 % of children) was not associated with higher risk for AD either in the entire cohort (OR adj, 0.95; 95% CI, 0.79-1.14) or if stratified by family history of AD. In the I subgroup, but not in the NI subgroup, exclusive breast-feeding showed a significant protective effect on AD if compared with conventional cow's milk formula (ORadj, 0.64; 95% CI, 0.45-0.90). Conclusion: These findings do not support the hypothesis that exclusive breast-feeding is a risk factor for development of atopic dermatitis but is protective if compared with conventional cow's milk. Observational studies might not be able to effectively control for selection bias and reverse causation.
UR - http://www.scopus.com/inward/record.url?scp=2342602295&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2003.12.029
DO - 10.1016/j.jpeds.2003.12.029
M3 - Article
C2 - 15126993
AN - SCOPUS:2342602295
SN - 0022-3476
VL - 144
SP - 602
EP - 607
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -