Effect of aprotinin and C1-esterase inhibitor on activation of the plasma kallikrein-kinin system in vivo.

H. Hoffmann, M. Siebeck, O. Thetter, E. Fink, A. Philapitsch

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Infusion of dextran sulfate in pigs rapidly activates the intrinsic cascade of the coagulation system including plasma prokallikrein and leads to release of kinin by limited proteolysis of kininogen. In this model, strong suppression of the DXS-induced activation of the plasma kallikrein-kinin system is seen at plasma aprotinin levels above 400 KIU/ml and C1INH levels above 4 U/ml.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalProgress in clinical and biological research
Volume236 A
StatePublished - 1987

Fingerprint

Dive into the research topics of 'Effect of aprotinin and C1-esterase inhibitor on activation of the plasma kallikrein-kinin system in vivo.'. Together they form a unique fingerprint.

Cite this