Effect of aprotinin and C1-esterase inhibitor on activation of the plasma kallikrein-kinin system in vivo.

H. Hoffmann; M. Siebeck; O. Thetter; E. Fink; A. Philapitsch

Effect of aprotinin and C1-esterase inhibitor on activation of the plasma kallikrein-kinin system in vivo.

H. Hoffmann, M. Siebeck, O. Thetter, E. Fink, A. Philapitsch

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Abstract

Infusion of dextran sulfate in pigs rapidly activates the intrinsic cascade of the coagulation system including plasma prokallikrein and leads to release of kinin by limited proteolysis of kininogen. In this model, strong suppression of the DXS-induced activation of the plasma kallikrein-kinin system is seen at plasma aprotinin levels above 400 KIU/ml and C1INH levels above 4 U/ml.

Original language	English
Pages (from-to)	159-164
Number of pages	6
Journal	Progress in clinical and biological research
Volume	236 A
State	Published - 1987

Cite this

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title = "Effect of aprotinin and C1-esterase inhibitor on activation of the plasma kallikrein-kinin system in vivo.",

abstract = "Infusion of dextran sulfate in pigs rapidly activates the intrinsic cascade of the coagulation system including plasma prokallikrein and leads to release of kinin by limited proteolysis of kininogen. In this model, strong suppression of the DXS-induced activation of the plasma kallikrein-kinin system is seen at plasma aprotinin levels above 400 KIU/ml and C1INH levels above 4 U/ml.",

author = "H. Hoffmann and M. Siebeck and O. Thetter and E. Fink and A. Philapitsch",

year = "1987",

language = "English",

volume = "236 A",

pages = "159--164",

journal = "Progress in clinical and biological research",

issn = "0361-7742",

publisher = "John Wiley & Sons Inc.",

}

TY - JOUR

T1 - Effect of aprotinin and C1-esterase inhibitor on activation of the plasma kallikrein-kinin system in vivo.

AU - Hoffmann, H.

AU - Siebeck, M.

AU - Thetter, O.

AU - Fink, E.

AU - Philapitsch, A.

PY - 1987

Y1 - 1987

N2 - Infusion of dextran sulfate in pigs rapidly activates the intrinsic cascade of the coagulation system including plasma prokallikrein and leads to release of kinin by limited proteolysis of kininogen. In this model, strong suppression of the DXS-induced activation of the plasma kallikrein-kinin system is seen at plasma aprotinin levels above 400 KIU/ml and C1INH levels above 4 U/ml.

AB - Infusion of dextran sulfate in pigs rapidly activates the intrinsic cascade of the coagulation system including plasma prokallikrein and leads to release of kinin by limited proteolysis of kininogen. In this model, strong suppression of the DXS-induced activation of the plasma kallikrein-kinin system is seen at plasma aprotinin levels above 400 KIU/ml and C1INH levels above 4 U/ml.

UR - http://www.scopus.com/inward/record.url?scp=0023086098&partnerID=8YFLogxK

M3 - Article

C2 - 2441405

AN - SCOPUS:0023086098

SN - 0361-7742

VL - 236 A

SP - 159

EP - 164

JO - Progress in clinical and biological research

JF - Progress in clinical and biological research

ER -

Effect of aprotinin and C1-esterase inhibitor on activation of the plasma kallikrein-kinin system in vivo.

Abstract

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