Effect of angiotensin peptides on PAI-1 expression and production in human adipocytes

T. Skurk, Y. M. Lee, K. Röhrig, H. Hauner

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Angiotensin (Ang) II is the active component of the renin-angiotensin-system (RAS), but its degradation products have also been shown to exhibit biological activity. This system, which mainly controls blood pressure and electrolyte homeostasis, was recently found to be completely expressed in human adipose tissue. The major determinant in the fibrinolytic system is the plasminogen activator inhibitor-1 (PAI-1). Both PAI-1 and components of the RAS are over-expressed in the obese state. We have recently shown that Ang II is able to induce PAI-1 expression and release via the AT1-receptor in human fat cells in primary culture, and have provided the first evidence that two metabolites, Ang III and Ang IV, may have a similar stimulatory effect on PAI-1 release. We have now performed additional experiments to further characterize the role of the ang̀iotensin peptides in the production of PAI-1. Ang III and Ang IV showed a time- and dose-dependent stimulation of PAI-1 protein release. Concomitantly, mRNA-levels were markedly elevated. Using specific receptor blockers, all angiotensin peptides seem to induce PAI-1 expression via the angiotensin receptor subtype 1. However, components of the renin-angiotensin-system seem to play an important role in the control of fibrinolysis in adipose tissue. We conclude that PAI-1 production by adipose tissue may contribute to the elevated thromboembolic risk in obesity.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalHormone and Metabolic Research
Volume33
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Adipose tissue
  • Angiotensin II
  • Fibrinolysis
  • Hypertension
  • Obesity
  • Plasminogen activator inhibitor-1
  • Renin-angiotensin-system

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