Effect of abrocitinib on skin biomarkers in patients with moderate-to-severe atopic dermatitis

Emma Guttman-Yassky, Paola Facheris, Pedro Jesus Gomez-Arias, Ester Del Duca, Joel Correa Da Rosa, Stephan Weidinger, Robert Bissonnette, April W. Armstrong, Julien Seneschal, Kilian Eyerich, Yeriel D. Estrada, Swaroop N. Bose, Dan Xu, Allshine Chen, Svitlana Tatulych, Erman Güler, Gary Chan, Karen M. Page, Urs Kerkmann

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: This is the first report on the effects of abrocitinib, a Janus kinase 1–selective inhibitor, on the expression of skin biomarkers in patients with moderate-to-severe atopic dermatitis (AD). Methods: JADE MOA (NCT03915496) was a double-blind Phase 2a trial. Adults were randomly assigned 1:1:1 to receive monotherapy with once-daily abrocitinib 200 mg, abrocitinib 100 mg, or placebo for 12 weeks. The primary endpoint was change from baseline in markers of inflammation (matrix metalloproteinase [MMP]-12), epidermal hyperplasia (keratin-16 [KRT16]), T-helper 2 (Th2) immune response (C-C motif chemokine ligand [CCL]17, CCL18, and CCL26), and Th22 immune response (S100 calcium binding protein A8, A9, and A12 [S100A8, S100A9, and S100A12]) in skin through 12 weeks. Results: A total of 46 patients received abrocitinib 200 mg (n = 14), abrocitinib 100 mg (n = 16), or placebo (n = 16). Abrocitinib improved AD clinical signs and reduced itch. Gene expression of MMP-12, KRT16, S100A8, S100A9, and S100A12 was significantly decreased from baseline with abrocitinib 200 mg (at Weeks 2, 4, and 12) and abrocitinib 100 mg (at Weeks 4 and 12) in a dose-dependent manner. Abrocitinib 200 mg resulted in significant decreases from baseline in CCL17 expression at Week 12 and CCL18 expression at Weeks 2, 4, and 12; no significant decreases were observed for CCL26. Conclusions: Alongside improvements in clinical signs and symptoms of AD, 12 weeks of abrocitinib treatment resulted in downregulation of genes associated with inflammation, epidermal hyperplasia, and Th2 and Th22 immune responses in the skin of patients with moderate-to-severe AD.

Original languageEnglish
Pages (from-to)1258-1270
Number of pages13
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume79
Issue number5
DOIs
StatePublished - May 2024
Externally publishedYes

Keywords

  • atopic dermatitis
  • biomarkers
  • dermatology

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